Obiettivo NDL-PCBs are poorly characterised from a toxicological point of view, and to date, there is no health risk assessment available. Since NDL-PCBs constitute a major part of the PCBs found in food and human tissues it has become an urgent matter to advance the understanding of their toxicity. The topic has recently been discussed in several organisations, which provide advice to the regulators. Neurobehavioural, reproductive and developmental toxicity, and tumour promotion have been pointed out by the European commission to be of particular concern. The present project proposal ATHON addresses all of these effects, as well as indicators for immunotoxicity, endocrine disturbances, general liver toxicity, and NDL-PCB metabolism. Studies will be designed to meet the quantitative and qualitative requirements on toxicological data for use in the hazard assessment procedures. Efforts will be made to identify toxicological mechanisms and outcomes, specific for NDL-PCBs. Such knowledge is a prerequisite for future meaningful studies of NDL-PCB epidemiology. The major objectives are to: 1) establish quality-controlled experimental in vivo and in vitro models for studies of NDL-PCBs 2) provide toxicokinetic data of for NDL-PCBs 3) provide quantitative and qualitative toxicity profiles for NDL-PCBs 4) provide a new classification strategy for NDL-PCB congeners based on effect biomarker information 5) provide an up-to-date compilation and evaluation of toxicological effect and exposure data on NDL-PCBs and PCB metabolites A multidisciplinary approach is required to achieve the objectives, and a consortium with a wide range of expertise has been established. Non-EU partners, project collaborators, and an international advisory board are involved to meet the international dimension of the problem. Clearly, with this approach ATHON will provide missing critical health hazard information and clarify biological mechanisms underlying the various types of toxicity induced by NDL-PCBs. Campo scientifico medical and health scienceshealth sciencespublic healthepidemiologyagricultural sciencesanimal and dairy sciencedairysocial sciencessociologygovernancecrisis managementmedical and health sciencesclinical medicineendocrinologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Parole chiave classification strategy developmental toxicity endocrine disruption health hazard evaluation immunotoxicity liver toxicity neurotoxicity placental transfer toxicokinetics tumour promotion Programma(i) FP6-FOOD - Food Quality and Safety: Thematic priority 5 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) FOOD-2004-T5.4.8.4 - Risk assessment of non-dioxin-like polychlorinated biphenyls (PCBs) Invito a presentare proposte FP6-2004-FOOD-3-B Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore KAROLINSKA INSTITUTET Contributo UE Nessun dato Indirizzo Nobels väg. 5 STOCKHOLM Svezia Mostra sulla mappa Costo totale Nessun dato Partecipanti (14) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK NV Belgio Contributo UE Nessun dato Indirizzo Boeretang 200 MOL Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato VETERINARY RESEARCH INSTITUTE Cechia Contributo UE Nessun dato Indirizzo Hudcova 70 BRNO Mostra sulla mappa Costo totale Nessun dato FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPE FELIPE Spagna Contributo UE Nessun dato Indirizzo Avenida Autopista del Saler, 16 VALENCIA Mostra sulla mappa Costo totale Nessun dato TERVEYDEN JA HYVINVOINNIN LAITOS (NATIONAL INSTITUTE FOR HEALTH AND WELFARE) Finlandia Contributo UE Nessun dato Indirizzo Mannerheimintie 166 HELSINKI Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato INSTITUT FÜR WISSENSCHAFT UND FORSCHUNG Germania Contributo UE Nessun dato Indirizzo Buerkle de la Camp Platz 1 BOCHUM Mostra sulla mappa Costo totale Nessun dato TECHNISCHE UNIVERSITÄT KAISERSLAUTERN Germania Contributo UE Nessun dato Indirizzo Gottlieb-Daimler-Strasse KAISERSLAUTERN Mostra sulla mappa Costo totale Nessun dato ISTITUTO DI RICERCHE FARMACOLOGICHE "MARIO NEGRI" Italia Contributo UE Nessun dato Indirizzo Via Eritrea 62 MILANO Mostra sulla mappa Costo totale Nessun dato UTRECHT UNIVERSITY Paesi Bassi Contributo UE Nessun dato Indirizzo Heidelberglaan 8 UTRECHT Mostra sulla mappa Costo totale Nessun dato VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIËNTENZORG Paesi Bassi Contributo UE Nessun dato Indirizzo De Boelelaan 1105 AMSTERDAM Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITETET I OSLO Norvegia Contributo UE Nessun dato Indirizzo Problemveien 7 OSLO Mostra sulla mappa Costo totale Nessun dato UMEA UNIVERSITET Svezia Contributo UE Nessun dato Indirizzo Universitetsomradet UMEA Mostra sulla mappa Costo totale Nessun dato UNIVERSITY HOSPITALS BRISTOL NHS FOUNDATION TRUST Regno Unito Contributo UE Nessun dato Indirizzo Trust Headquarters, Marlborough St BRISTOL Mostra sulla mappa Costo totale Nessun dato HEALTH CANADA Canada Contributo UE Nessun dato Indirizzo 1 de la Columbine, Environmental Health Centre (Building 8), Tunney's Pasture OTTAWA Mostra sulla mappa Costo totale Nessun dato DEUTSCHE GESETZLICHE UNFALLVERSICHERUNG EV - DGUV Germania Contributo UE Nessun dato Indirizzo Alte Heerstrasse 111 SANKT AUGUSTIN Mostra sulla mappa Costo totale Nessun dato