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Development of improved tools for detection of paratuberculosis in livestock, M.paratuberculosis in food and for the assessment of the risk of human exposure

Project information

Grant agreement ID: 23106

  • Start date

    1 June 2006

  • End date

    31 May 2010

Funded under:

FP6-FOOD

  • Overall budget:

    € 5 414 056

  • EU contribution

    € 3 940 000

Coordinated by:

STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK

Netherlands

Objective

This project directly addresses Task 5.4.6.10 ( Mycobacterium avium sub-species paratuberculosis (Map) diagnosis and control of the thematic area 5 (Food Quality and Safety). Paratuberculosis, a chronic wasting disease in ruminants, is causing significant production losses to both dairy and meat producers, due to a decreasing milk yield, loss of body weight and early replacements. The absence of adequate diagnostic tools for early detection of sub-clinically infected livestock severely interferes with animal welfare; since affected animals are send to slaughter only when they are in an advanced stage of disease. In addition, animals with sub-clinical disease will suffer additionally from an increased susceptiblity to secondary infections.

The presence of life Map in retail milk in combination with its possible association with Crohn's disease in humans has resulted in consumer concerns, specifically among CD patients in the EU and the US, for quality and safety of milk and dairy products. This potential zoonotic role, the human exposure to map via milk and the fact that this relation cannot be proved or disproved, is reason for great concern.

This latent food safety issue, combined with the economic and welfare impact the disease has on animal husbandry in the EU strengthen the importance of an effective paratuberculosis control. This project seeks to address the serious shortfalls in the current methodology for (early) diagnosis of paratuberculosis, in livestock as well as in humans, for the detection of Map in food, for the risk-assessment of human exposure via the foodchain to Map and to further investigate the possible role of Map in the aetiology of Crohn's disease.

To be able to address the multifaceted problem of paratuberculosis an EU-led multidisciplinary consortium will be established containing expertise in mycobacteriology, immunology, test-development, molecular biology, genetics.

Coordinator

STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK

Address

Costerweg 50
9101 Wageningen

Netherlands

Participants (27)

QUEEN'S UNIVERSITY BELFAST

United Kingdom

SCOTTISH AGRICULTURAL COLLEGE

United Kingdom

NATIONAL VETERINARY INSTITUTE

Norway

UNIVERSIDAD COMPLUTENSE MADRID

Spain

UNIVERSIDAD DE LEON

Spain

INSTITUTO VASCO DE INVESTIGACION Y DESARROLLO AGRARIO - NEIKER AB

Spain

VETRINARY RESEARCH INSTITUTE

Czechia

TECHNICAL UNIVERSITY OF DENMARK

Denmark

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

France

TEAGASC

Ireland

ST GEORGE'S UNIVERSITY OF LONDON

United Kingdom

AGENCE FRANCAISE DE SECURITE SANITAIRE DES ALIMENTS

France

THE ROYAL VETERINARY COLLEGE

United Kingdom

UNIVERSITY OF COPENHAGEN

Denmark

EIGEN VERMOGEN VAN HET INSTITUUT VOOR LANDBOUW EN VISSERIJONDERZOEK

Belgium

STATENS SERUM INSTITUT

Denmark

VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG

Netherlands

NIZO FOOD RESEARCH B.V.

Netherlands

VETERINARY AND AGROCHEMICAL RESEARCH CENTRE

Belgium

ADIAGENE

France

INNOVATIVE DIAGNOSTIC VET

France

MOREDUN RESEARCH INSTITUTE

United Kingdom

UNIVERSITY OF OTAGO

New Zealand

MCGILL UNIVERSITY HEALTH CENTRE RESEARCH INSTITUTE

Canada

INSTITUTO NACIONAL DE TECNOLOGÍA AGROPECUARIA

Argentina

MICHIGAN STATE UNIVERSITY

United States

FEDERAL RESEARCH CENTRE FOR NUTRITION AND FOOD, INSTITUTE FOR HYGIENE AND FOOD SAFETY

Germany

Project information

Grant agreement ID: 23106

  • Start date

    1 June 2006

  • End date

    31 May 2010

Funded under:

FP6-FOOD

  • Overall budget:

    € 5 414 056

  • EU contribution

    € 3 940 000

Coordinated by:

STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK

Netherlands