Objetivo GENEPI 2 aims at the qualitative and quantitative further development of the European tissue bank and database GENEPI-ENTB, established with EURATOM support in FP5. It is dedicated to research in radiation effects and in the genetic determinants of the variation in individual radio-sensitivity. With tissues from more than 4.200 patients linked to solid outcome data stored, GENEPI is currently the largest infrastructure in this field worldwide.The final aim is to more than triple that number to enable the selection of statistically relevant groups for analysis and to keep all future avenues of research open. An inestimable plus value for the GENEPI tissues (DNA or lymphocytes and other normal and tumour tissues) obtained from radiotherapy patients is the database linked to it. For each tissue, treatment data (dose distributions with dose gradients, total dose, dose per fraction) and outcome data are recorded.It will be a major objective for GENEPI 2 to develop the tools to make these rich data easily searchable and available for distant querying. Another powerful new feature to be developed in GENEPI 2 aims at creating a logistical shortcut for the quest to identify the hypersensitive phenotype. Tissues will be collected from a group of patients who demonstrated an unexpectedly severe response to RT (+/- 1 out of 1000). This action will necessitate the collaboration of a large segment of the European RT community. Major attention will be paid to all aspects of quality assurance. A steering committee will oversee all protocols, use and access.Finally, a close collaboration will be established with the "GENEPI-Low RT" consortium intent on using the GENEPI resource for its proposed "Low dose radiosensitivity" project submitted for this call as well as with other candidate users a.o. a working party preparing a joint study on radiation response to high doses. ESTRO will be the custodian of ethical issues and handle dissemination, training and project management. Ámbito científico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencescomputer and information sciencesdatabasesnatural sciencesbiological sciencesgeneticsDNA Palabras clave biobank databases databases-biobank-genetic profiling individual low/high dose radiosensitivity occupational/medical/environmental exposures radiation protection radiation protection-recording/scoring/documenting of radiation effects recording/scoring/documenting of radiation effects Programa(s) FP6-EURATOM-RADPROT - Thematic priority - Radiation Protection as part of the specific framework programme for the European Atomic Energy Community, within the multi-annual framework programme 2002-2006. Tema(s) RAD PROT-2005/6-3.3.1.1-2 - Cellular and molecular biology research on the effects of low and protracted doses Convocatoria de propuestas EURATOM-2005-6-FIXEDDEADLINE Consulte otros proyectos de esta convocatoria Régimen de financiación STREP - Specific Targeted Research Project Coordinador EUROPEAN SOCIETY FOR THERAPEUTIC RADIOLOGY AND ONCOLOGY Aportación de la UE Sin datos Dirección Av. E. Mounier, 83 BRUXELLES Bélgica Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos Participantes (7) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSITEIT MAASTRICHT Países Bajos Aportación de la UE Sin datos Dirección Minderbroedersberg 4-6 MAASTRICHT Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos TECHNISCHE UNIVERSITAET DRESDEN Alemania Aportación de la UE Sin datos Dirección Mommsenstrasse 7 DRESDEN Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos UNIVERSITE CATHOLIQUE DE LOUVAIN Bélgica Aportación de la UE Sin datos Dirección 1 Place De L'Universite LOUVAIN-LA-NEUVE Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos POLITECHNIKA SLASKA Polonia Aportación de la UE Sin datos Dirección Ul. Akademicka 2 GLIWICE Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos KATHOLIEKE UNIVERSITEIT LEUVEN Bélgica Aportación de la UE Sin datos Dirección Oude Markt 13 LEUVEN Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos MEDLAWCONSULT Países Bajos Aportación de la UE Sin datos Dirección Javastraat, 76 THE HAGUE Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos EQUAL-ESTRO SAS Francia Aportación de la UE Sin datos Dirección Rue Louis Philippe 20 bis NEUILLY-SUR-SEINE Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos
