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Dynamic analysis of physiological Networks

Project information

Grant agreement ID: 018474-2

  • Start date

    1 April 2006

  • End date

    31 March 2009

Funded under:

FP6-IST

  • Overall budget:

    € 2 109 300

  • EU contribution

    € 1 900 000

Coordinated by:

ATOS ORIGIN SOCIEDAD ANONIMA ESPANOLA

Spain

Objective

Note - This full proposal was previously submitted in the short proposal with the name 'PhysioNet'.

Physiological signals as output of the human complex system are typically nonlinear and non-stationary, and much information is hidden in the dynamics of their fluctuations. By applying conventional analysis techniques based on averaged quantities and other features of histogram and classical power spectrum analysis, some important characteristic properties of the signal dynamics are neglected.

Our investigations strongly indicate that in particular the scaling behaviour of the fluctuations plays an important role for distinguishing between healthy and pathological cases. By adapting and extending recent methods developed in modern statistical physics and nonlinear mathematics, it has been shown that the fluctuations of heartbeat and other neurally-controlled signals exhibit unanticipated hidden information (order) in the form of self-similarity, scaling structure, multifractality and long-term memory.

In the present proposal we suggest to extend our previous research on the properties of each particular signal. The physiological functions to be studied are the cardio vascular capacities, brain activity (EEG), motor control, gait, posture, sleep and sympathetic and parasympathetic effects. Algorithms to assess the long-term effects and Inter- relations between signals representing these functions are at the core of this proposal. The simultaneous collection of several long-term signals will enable the construction of physiological networks using dynamical synchronization and cross-correlations patterns, whose momentary state together with the properties of each signal can give a picture of the health status of an individual.

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Coordinator

ATOS ORIGIN SOCIEDAD ANONIMA ESPANOLA

Address

Calle De Albarracin 25
28037 Madrid

Spain

Participants (8)

BAR ILAN UNIVERSITY

Israel

BEACON TECH LTD.

Israel

CHARITE-UNIVERSITATSMEDIZIN BERLIN

Germany

EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRICH

Switzerland

FONDAZIONE ISTITUTO PER L'INTERSCAMBIO SCIENTIFICO

Italy

JUSTUS LIEBIG UNIVERSITAET GIESSEN

Germany

OULUN YLIOPISTO

Finland

THE FOUNDATION FOR MEDICAL RESEARCHINFRASTRUCTURAL DEVELOPMENT AND HEALTH SERVICES NEXT TO THE MEDICAL CENTER TEL AVIV

Israel

Project information

Grant agreement ID: 018474-2

  • Start date

    1 April 2006

  • End date

    31 March 2009

Funded under:

FP6-IST

  • Overall budget:

    € 2 109 300

  • EU contribution

    € 1 900 000

Coordinated by:

ATOS ORIGIN SOCIEDAD ANONIMA ESPANOLA

Spain