Objectif CAPSANT Neurotechnologies is an emerging SME that spun out from the University of Southampton (UK). The scientific and technological basis of the company, that makes its originality and strength on the market, is its unique ability to screen drugs in a fully relevant ex vivo set up.In this set up, experimental models of-up to now- stroke or epilepsy can be analysed in brain slices maintained in organotypic cultures, and outcome measures of neuronal alteration and death provide quantified clues about the protective effects of pharmacological compounds.This platform is currently used for high throughput screening by several industrial partners of CAPSANT Neurotechnologies. Independently, the academic team led by Dr Marc Peschanski at INSERM in Creteil, France, has developed in recent years an experimental model based upon an adaptation of the same methodology, that allows analysing potential therapeutics for an additional brain disease, namely glioblastoma.In addition to allowing proliferation and intra-parenchymal migration of tumour cells to be quantified, this technique (called ISIS for intra-slice implantation system) has revealed instrumental to study tumour-induced angiogenesis. Several molecules endowed with anti-tumoral or anti-angiogenic potentials have already been successfully screened in this set up.The program proposed for this Marie-Curie fellowship directly stems from the obvious complementarity of the two R and D programs. Collaboration, in particular through extended periods of work by Marc Peschanski and members of his team at CAPSANT, will allow the transfer of technology to the company, extending its offer to industrial partners to screening for therapies applicable to brain tumours.Conversely, CAPSANT scientists will provide high level training to Marc Peschanski and his team to all techniques they master that allow functional analysis of brain slices, including in particular electrophysiology and proteomics. Champ scientifique medical and health sciencesbasic medicineneurologyepilepsynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesclinical medicinesurgerynatural sciencesmathematicspure mathematicsmathematical analysisfunctional analysismedical and health sciencesbasic medicineneurologystroke Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Thème(s) MOBILITY-1.3 - Marie Curie Host Fellowships - Transfer of knowledge (TOK) Appel à propositions FP6-2002-MOBILITY-3 Voir d’autres projets de cet appel Régime de financement TOK - Marie Curie actions-Transfer of Knowledge Coordinateur CAPSANT NEUROTECHNOLOGIES Contribution de l’UE Aucune donnée Adresse 2 Venture Rd, Chilworth Science Park SOUTHAMPTON Royaume-Uni Voir sur la carte Coût total Aucune donnée Participants (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE. France Contribution de l’UE Aucune donnée Adresse 101 Rue de Tolbiac PARIS Voir sur la carte Coût total Aucune donnée
