Skip to main content

Host-pathogen interaction systems as tools to identify antifungal targets in C. Albicans and C. Dubliniensis

Objective

One of the major tasks the Life Science industry faces in the coming years is to validate a plethora of targets for treatment of various diseases and the identification of novel lead compounds to generate novel pharmaceutics specifically acting on the targets identified. "CanTrain" will train both early and experienced researchers in the methodologies necessary for drug development, including target identification, target validation, development of cell-based screening assays all of which is caused by fungal pathogens, especially strategies for the identification of novel antifungal drugs. Fungal infections have increased largely in the recent years, mostly due to immuno- compromised patients in intensive care units.

Despite intensive therapy, a high proportion of these patients contract systemic mycosis. CanTrain attempts to establish approaches leading to the development of novel anti-fungal compounds by combining the expertise of 11 partners in cellular sensor systems and signalling pathways controlling morph ogenesis and virulence, model systems for host-pathogen interaction, assay development and drug screening technologies. This network will not only give insight into mechanisms of host-pathogen interactions in general, but also bridge the gap between the identification of potential target proteins from the pathogen required for colonisation and infection of the host. CanTrain will enable the identification of antifungal compounds by establishing intelligent cell-based screening assays considering the host environment.

These cell-based screening assays will employ reporter genes activated by signalling pathways required for pathogenesis. The experimental approaches of CanTrain comprise state-of-the-art technologies, including global transcriptome and proteome analysis of pathogens during the infection process using in vitro host-pathogen tissue systems.

Call for proposal

FP6-2002-MOBILITY-1
See other projects for this call

Funding Scheme

RTN - Marie Curie actions-Research Training Networks

Coordinator

FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW
Address
Rijvisschestraat 120
Gent-zwijnaarde
Belgium

Participants (11)

COMENIUS UNIVERSITY IN BRATISLAVA
Slovakia
Address
Safarikovo Namestie 6
Bratislava 16
EMC MICROCOLLECTIONS GMBH
Germany
Address
Sindelfinger Str. 3
Tuebingen
FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
Address
Hansastrasse 27C
München
INSTITUTE OF PHYSIOLOGY, THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC
Czechia
Address
Videnska 1083
Prague
LUDWIG INSTITUTE FOR CANCER RESEARCH - STOCKHOLM BRANCH
Sweden
Address
Karolinska Institutet
Stockholm
MEDIZINISCHE UNIVERSITÄT WIEN
Austria
Address
Spitalgasse 23
Vienna
STOCKHOLMS UNIVERSITET
Sweden
Address
Universitetsvägen 10
Stockholm
THE PROVOST FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (HEREINAFTER CALLED TCD)
Ireland
Address
College Green
Dublin
THE UNIVERSITY OF MANCHESTER
United Kingdom
Address
Oxford Road
Manchester
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
Address
Avenida De Seneca 2
Madrid
UNIVERSITÀ  DEGLI STUDI DI MILANO
Italy
Address
Via Festa Del Perdono 7
Milano