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Host-pathogen interaction systems as tools to identify antifungal targets in C. Albicans and C. Dubliniensis

Objective

One of the major tasks the Life Science industry faces in the coming years is to validate a plethora of targets for treatment of various diseases and the identification of novel lead compounds to generate novel pharmaceutics specifically acting on the targets identified. "CanTrain" will train both early and experienced researchers in the methodologies necessary for drug development, including target identification, target validation, development of cell-based screening assays all of which is caused by fungal pathogens, especially strategies for the identification of novel antifungal drugs. Fungal infections have increased largely in the recent years, mostly due to immuno- compromised patients in intensive care units.

Despite intensive therapy, a high proportion of these patients contract systemic mycosis. CanTrain attempts to establish approaches leading to the development of novel anti-fungal compounds by combining the expertise of 11 partners in cellular sensor systems and signalling pathways controlling morph ogenesis and virulence, model systems for host-pathogen interaction, assay development and drug screening technologies. This network will not only give insight into mechanisms of host-pathogen interactions in general, but also bridge the gap between the identification of potential target proteins from the pathogen required for colonisation and infection of the host. CanTrain will enable the identification of antifungal compounds by establishing intelligent cell-based screening assays considering the host environment.

These cell-based screening assays will employ reporter genes activated by signalling pathways required for pathogenesis. The experimental approaches of CanTrain comprise state-of-the-art technologies, including global transcriptome and proteome analysis of pathogens during the infection process using in vitro host-pathogen tissue systems.

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Coordinator

FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW

Address

Rijvisschestraat 120
Gent-Zwijnaarde

Belgium

Participants (11)

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COMENIUS UNIVERSITY IN BRATISLAVA

Slovakia

EMC MICROCOLLECTIONS GMBH

Germany

FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Germany

INSTITUTE OF PHYSIOLOGY, THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC

Czechia

LUDWIG INSTITUTE FOR CANCER RESEARCH - STOCKHOLM BRANCH

Sweden

MEDIZINISCHE UNIVERSITÄT WIEN

Austria

STOCKHOLMS UNIVERSITET

Sweden

THE PROVOST FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (HEREINAFTER CALLED TCD)

Ireland

THE UNIVERSITY OF MANCHESTER

United Kingdom

UNIVERSIDAD COMPLUTENSE DE MADRID

Spain

UNIVERSITÀ  DEGLI STUDI DI MILANO

Italy

Project information

Grant agreement ID: 512481

  • Start date

    1 March 2005

  • End date

    28 February 2009

Funded under:

FP6-MOBILITY

Coordinated by:

FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW

Belgium