Obiettivo Colorectal cancer is a leading cause of cancer in European non-smokers. Dietary changes might reduce the incidence up to 70%, according to epidemiological reports, but the dietary factor initiating them is not known. Researchers in the proposed outgoing organisation have recently found that rats given a diet with reduced thiamin (vitamin B1) for 4 months have small patches in their colons, ACF, that are recognised as precursors to colon cancer (Bruce et al, Cancer Lett. 2003). Furthermore, they have found with studies in tissue culture that the toxic effects of reduced thiamin are markedly worse when the cells are exposed to an oxidative stress (Shangari et al, Biochem. Soc. Trans. 2003).We want to use these preliminary findings as a base to find out whether the combination of reduced thiamin and an oxidative stress from cooked food increases the formation of ACF in the colons of rats at 4 months and whether it will result in colon cancer if extended for a longer period. This will be extended to other natural sources of oxidative stress such as red meat and sucrose. We also want to investigate biochemical measures from blood samples from these animals that can be used as biomarkers of thiamin deficiency and oxidative stress. The final stage would be to correlate biomarkers with the development of colon carcinogenesis in vivo. Our expectation is that these diet changes, reduced thiamin and cooked food, will result in colon cancer in the rat, and that the biochemical measures associated with the development of the tumours can be used to assess this risk in humans. Campo scientifico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineoncologycolorectal cancermedical and health scienceshealth sciencesnutritionnatural scienceschemical sciencesorganic chemistryheterocyclic compoundsnatural scienceschemical sciencesorganic chemistryamines Parole chiave ACF Antioxidant Biomarker Cancer Colon Haem Prevention Rat Sucrose Thiamin Vitamin B1 Vitamin_B1 Programma(i) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Argomento(i) MOBILITY-2.2 - Marie Curie Outgoing International Fellowships (OIF) Invito a presentare proposte FP6-2002-MOBILITY-6 Vedi altri progetti per questo bando Meccanismo di finanziamento OIF - Marie Curie actions-Outgoing International Fellowships Coordinatore INSTITUT NATIONAL DE RECHERCHE AGRONOMIQUE (FRANCE) Contributo UE Nessun dato Indirizzo 147, Rue de l'Universite PARIS Francia Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (1) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto THE GOVERNING BODY OF TH UNIVERSITY OF TORONTO Canada Contributo UE Nessun dato Indirizzo TORONTO, ONTARIO Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato
