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European network to promote research into uncommon cancers in adults and children: Pathology, Biology and Genetics of Bone Tumours

Objective

Primary bone tumours are rare, accounting ~0.2% of the cancer burden. Children and young adolescents are frequently affected. Their aggressiveness has major impact on morbidity and mortality. Though progress has been made in pathological and genetic typing, the aetiology is largely unknown. Though advances in therapeutic approaches increased survival, significant numbers of patients (~40%) still die. Within the EuroBoNeT integration will be achieved by staff exchange and website-based discussion forums to increase and disseminate knowledge of primary bone tumours at the molecular level for development of new tools for patient care and cure and technology. With this integration exchange of material (virtual BioBank), Standard Operating Protocols and the use of technology platforms will enable us to obtain statistical significant datasets, otherwise not achievable due to the rareness and large number of sub entities.

A joint programme will contribute in obtaining molecular portraits of tumours, separated in 4 research lines (RL). In each RL the biology of the separate group (RL1: cartilaginous tumours; RL2: osteogenic tumours and related sarcomas; RL3: osteoclastogenesis and Giant cell tumours of bone; and RL4: Ewing family of tumours) will be examined by genome wide expression and genomic aberration studies. More specific hypothesis driven approaches will be investigated by RNA/protein expression and mutation analysis. Knowledge on normal growth and differentiation will be gathered through in vitro studies.

This would lead to further understanding and identification of markers for malignant transformation and/or progression, as well as identification of therapeutic targets. Next to research, dissemination of knowledge will be achieved by training courses on bon e and soft tissue pathology for all interested. The last is required since patients usually do not present themselves at centres, which necessitates spreading of knowledge.

Call for proposal

FP6-2004-LIFESCIHEALTH-5
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Coordinator

LEIDEN UNIVERSITY MEDICAL CENTER
Address
Albinusdreef 2
9600 Leiden
Netherlands

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Participants (25)

ISTITUTI ORTOPEDICI RIZZOLI
Italy
Address
Via Di Barbiano 1/10
Bologna

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HELSINKI UNIVERSITY CENTRAL HOSPITAL
Finland
Address
Stenbackinkatu 9
100 Helsinki

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THE ROYAL ORTHOPAEDIC HOSPITAL NATIONAL HEALTH SERVICE TRUST
United Kingdom
Address
Bristal Road South, Northfield
Birmingham

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N. GOORMAGHTIGH INSTITUTE OF PATHOLOGY
Belgium
Address
De Pintelaan 185
Ghent

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UNIVERSITEIT ANTWERPEN
Belgium
Address
Prinsstraat 13
Antwerp

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HEINRICH-HEINE-UNIVERSITY DUESSELDORF, INST. OF PATHOLOGY
Germany
Address
Moorenstrasse 5
Duesseldorf

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UNIVERSITAT BERN
Switzerland
Address
Hochschulstrasse 4
Bern

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THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
University Offices, Wellington Square
Oxford

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FUNDACION DE INVESTIGACION DEL CANCER DE LA UNIVERSIDAD DE SALAMANCA (FICUS)
Spain
Address
Campus Miguel De Unamuno S/n
Salamanca

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OSLO UNIVERSITETSSYKEHUS HF
Norway
Address
Forskningsveien 2b
Oslo

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RIGSHOSPITALET
Denmark
Address
Blegdamsvej 9
Copenhagen

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LUND UNIVERSITY
Sweden
Address
Paradisgatan 5c
117 Lund

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KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Address
Oude Markt 13
Leuven

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WESTFALISCHE WILHELMSUNIVERSITAT MUNSTER
Germany
Address
Domagkstr.17
Munster

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UNITA LOCALE SOCIO-SANITARIA N. 9, REGIONE VENETO. HOSPITAL OF TREVISO, DEPARTMENT OF PATHOLOGY
Italy
Address
Borgo Cavalli N. 42
Treviso

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Links
SEMMELWEIS UNIVERSITY BUDAPEST
Hungary
Address
Ulloi Ut 26
Budapest

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STIFTUNG ORTHOPADISCHE UNIVERSITATSKLINIK HEIDELBERG
Germany
Address
Schlierbacher Landstrasse 200 A
Heidelberg

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PEPSCAN SYSTEMS B.V.
Netherlands
Address
Edelhertweg 15
2098 Lelystad

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MRC HOLLAND BV
Netherlands
Address
Hudsonstraat 68
Amsterdam

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ERASMUS MEDICAL CENTER ROTTERDAM
Netherlands
Address
Dr Molewaterplein 40
1738 Rotterdam

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UNIVERSITAT LEIPZIG
Germany
Address
Ritterstr.26
Leipzig

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UNIVERSITY COLLEGE OF LONDON
United Kingdom
Address
Gower Street
London

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PEPSCAN PRESTO B.V.
Netherlands
Address
Zuidersluisweg 2
2098 Lelystad

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SOLVO BIOTECHNOLOGY INC.
Hungary
Address
Béke U. 5/a
Szeged

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UNIVERSITAT DE VALÈNCIA. ESTUDI GENERAL
Spain
Address
Avda. Blasco Ibanez, 13
22085 Valencia

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