Objetivo The NEURONANO network proposes to integrate carbon nano-tubes (CNT) with multi-electrode array (MEA) technology to develop new generation biochips to help repair damaged central nervous system (CNS) tissues. This objective will be reached by adopting a mul ti-disciplinary approach and by crossing the boundaries among Materials Science, Nano and Micro-technology, and Neuroscience. The impact of carbon nan-otubes on multi-electrode array (MEA) technology and therefore on neuro-implant technology represents a fi rst step toward CNS nanoengineering. Our approach is to push ahead the application and fictionalization of carbon nano-tubes in the CNS by focusing on CNT chemistry, peptide and surface chemistry and two complex networks in cultures: the spinal cord (locomotor networks) and brain (hippocampus and neocortex networks). We will concentrate on the complex electrical activity of these networks once grown on implantable substrates. We are specifically interested in understanding how the components underlying electrical activity are organized when implemented with semi-conductive substrates, and how this organization changes in the presence of molecular cues or chronic stimulations. The research plan has three major aims: i) to answer fundamental questions ab out the biophysical interactions between nano-materials and neurons ii) to exploit carbon nano-tubes in the presentation of positive and negative cues, thus providing specific molecular environment to favour axonal regeneration and retargeting; iii) to deve lop the characterization of novel MEA/nano-tube integrated devices, for multi-site extra-cellular stimulation and recording. Ámbito científico natural sciencesbiological sciencesbiochemistrybiomoleculesnatural sciencesbiological sciencesdevelopmental biologymedical and health sciencesmedical biotechnologytissue engineeringnatural sciencesbiological sciencesneurobiologycomputational neuroscienceengineering and technologyother engineering and technologiesmicrotechnology Programa(s) FP6-NMP - Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new production processes and devices: thematic priority 3 under the 'Focusing and integrating community research' of the 'Integrating and strengthening the European Research Area' specific programme 2002-2006. Tema(s) NMP-2004-3.4.1.2-1 - Using nature as model for new nanotechnology-based processes Convocatoria de propuestas FP6-2004-NMP-TI-4 Consulte otros proyectos de esta convocatoria Régimen de financiación STREP - Specific Targeted Research Project Coordinador UNIVERSITA' DEGLI STUDI DI TRIESTE Aportación de la UE Sin datos Dirección Piazzale Europa 1 TRIESTE Italia Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos Participantes (5) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Francia Aportación de la UE Sin datos Dirección Rue Michel-Ange 3 PARIS Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos SZILARDTESTFIZIKAI ES OPTIKAI KUTATOINTEZETE-MAGYAR TUDOMANYOS AKADEMIA Hungría Aportación de la UE Sin datos Dirección Konkoly Thege u. 29-33 BUDAPEST Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos THE HEBREW UNIVERSITY OF JERUSALEM Israel Aportación de la UE Sin datos Dirección The Hebrew University, Mt Scopus JERUSALEM Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos MULTI CHANNEL SYSTEMS MCS GMBH Alemania Aportación de la UE Sin datos Dirección Aspenhaustrasse 21 REUTLINGEN Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE Suiza Aportación de la UE Sin datos Dirección Ecublens LAUSANNE Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos