The fast-pacing development of nanosciences and nanotechnologies is due to their great potential in improving the quality of life and in creating novel knowledge-based sustainable processes. This unprecedented "nano-pollution" may in fact pose risks to human (manufacturers and end-users) and animal health that we cannot evaluate at present because of the complete lack of appropriate instruments and bioassays. The DIPNA project aims at creating and validating these instruments and assays, and to propose to the EU and international communities new parameters for detection of nanopollution and evaluation of occupational nanotoxicology, in order to promote prevention and nanosafety in manufacturing and handling.
In this novel, multidisciplinary, multination al research project it will be developed a precise knowledge on nano-immunotoxicity, i.e. the impact of nanoparticles and nanopollution in general on human defence cells. This knowledge will be validated in comparison with nano-genotoxicity and nano-carcinogenicity, i.e. studying in parallel the activity of nanoparticles in a standardised transformation assay in vitro, to predict the potential pathological risks of exposure to nanoparticles for human health.
The project will be divided in 6 workpackages:
1. Production and physico-chemical characterisation of nanoparticles;
2. Evaluation of NP interaction with human defence cells: selection of representative cell systems;
3. Evaluation of one-to-one NP-cell interaction: definition of threshold and do se-dependent effects;
4. Evaluation of chronic and repeated exposure: eco-nanotoxicity;
5. Field validation and development platform;
6. Coordination, management, training, and public awareness.
The scientific knowledge gained during this project will provide the ground for a development platform, aiming at standardising and field-validating prototypic assays and related instruments for biodetection of nanoparticle-associated health risks.
Fields of science
- FP6-NMP - Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new production processes and devices: thematic priority 3 under the 'Focusing and integrating community research' of the 'Integrating and strengthening the European Research Area' specific programme 2002-2006.
Call for proposal
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