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Development of an integrated platform for nanoparticle analysis to verify their possible toxicity and the eco-toxicity

Objective

The fast-pacing development of nanosciences and nanotechnologies is due to their great potential in improving the quality of life and in creating novel knowledge-based sustainable processes. This unprecedented "nano-pollution" may in fact pose risks to human (manufacturers and end-users) and animal health that we cannot evaluate at present because of the complete lack of appropriate instruments and bioassays. The DIPNA project aims at creating and validating these instruments and assays, and to propose to the EU and international communities new parameters for detection of nanopollution and evaluation of occupational nanotoxicology, in order to promote prevention and nanosafety in manufacturing and handling.

In this novel, multidisciplinary, multination al research project it will be developed a precise knowledge on nano-immunotoxicity, i.e., the impact of nanoparticles and nanopollution in general on human defence cells. This knowledge will be validated in comparison with nano-genotoxicity and nano-carcinogenicity, i.e., studying in parallel the activity of nanoparticles in a standardised transformation assay in vitro, to predict the potential pathological risks of exposure to nanoparticles for human health.

The project will be divided in 6 workpackages:
1. Production and physico-chemical characterisation of nanoparticles;
2. Evaluation of NP interaction with human defence cells: selection of representative cell systems;
3. Evaluation of one-to-one NP-cell interaction: definition of threshold and do se-dependent effects;
4. Evaluation of chronic and repeated exposure: eco-nanotoxicity;
5. Field validation and development platform;
6. Coordination, management, training, and public awareness.

The scientific knowledge gained during this project will provide the ground for a development platform, aiming at standardising and field-validating prototypic assays and related instruments for biodetection of nanoparticle-associated health risks.

Call for proposal

FP6-2004-NMP-TI-4
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Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

CONSORZIO NAZIONALE INTERUNIVERSITARIO PER LE SCIENZE FISICHE DELLA MATERIA
Address
Via Della Vasca Navale, 84
Roma
Italy

Participants (9)

"PARIS LODRON" UNIVERSITAT SALZBURG
Austria
Address
Kapitelgasse 4-6
Salzburg
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
Address
Piazzale Aldo Moro 7
Roma
GRIMM AEROSOL TECHNIK
Germany
Address
Dorfstrasse 9
Ainring
VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK NV
Belgium
Address
Boeretang 200
Mol
CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA RECHERCHE ET DEVELOPMENT
Switzerland
Address
Jaquet-droz 1
Neuchâtel
COMMISSION OF THE EUROPEAN COMMUNITIES - DIRECTORATE GENERAL -JOINT RESEARCH CENTRE
Belgium
Address
200 Rue De La Loi
Bruxelles
FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V
Germany
Address
Hansastraße 27C
München
FUNDACIÓ PRIVADA INSTITUT CATALA DE NANOTECNOLOGIA
Spain
Address
Campus De La Uab Edifici C
Bellaterra
UNIVERSITÀ DEGLI STUDI MAGNA GRAECIA DI CATANZARO
Italy
Address
Campus Universitario Germaneto, Viale Europa-località Germaneto
Catanzaro