Objective The common carp is the most important farmed freshwater fish species in the world. Eastern European carp genebanks have been responsible for the selective improvement of carp for intensive and semi-intensive pond culture in Europe and their dissemination worldwide. Several serious disease problems such as Koi herpesvirus (KHV), and erythrodermatitis (Aeromonas salmonicida and A. hydrophila) threaten carp farming in many countries. Selection in carp has tended to develop high performing but inbred strains f or crossbreeding.The inclusion of disease and stress resistance as traits within breeding programmes will require the use of modern quantitative and molecular genetic tools. Disease resistance has proved to be a difficult trait to assess and improve in fish, direct challenges on potential broodstock run the risk of turning such fish into carriers. Functional genomics, proteomics and gene mapping will identify candidate genes and QTLs for resistant fish without a challenge.Heritability estimates for viral and bacterial resistance and genetic correlation to performance traits will be assessed. Differences in gene expression within high and low, viral and bacterial, resistance families with and without challenge will be assessed using a 20K gene carp micro-array. Differences in serum/plasma protein expression and immunological parameters will also be assessed. Congruence between expression levels and protein production will provide evidence for the importance of particular genes or Gene ontologys (GO) in these processes.Progress will also be made towards to development of a second- generation medium resolution gene map that will be an important tool for the future development of improved strains of carp. The results from the quantitative genetic and molecular data will be modelled to inform on the optimum design of future practical breeding programmes. This information being disseminated via established international networks. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencescomputer and information sciencesdatabasesnatural sciencesbiological sciencesfreshwater biologynatural sciencesphysical sciencesopticsmicroscopynatural sciencesbiological scienceszoologyichthyology Programme(s) FP6-POLICIES - Policy support: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) POLICIES-1.3 - The modernisation and sustainability of fisheries policies Call for proposal FP6-2004-SSP-4 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator RESEARCH INSTITUTE OF FISHERIES, AQUACULTURE AND IRRIGATION EU contribution No data Address Anna liget 8. 0 SZARVAS Hungary See on map Links Website Opens in new window Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITY OF STIRLING. United Kingdom EU contribution No data Address STIRLING See on map Links Website Opens in new window Total cost No data THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS ACTING THROUGH THE CENTRE FOR ENVIRONMENT, FISHERIES AND AQUACULTURE SCIENCE United Kingdom EU contribution No data Address Pakefield Road LOWESTOFT, SUFFOLK See on map Links Website Opens in new window Total cost No data THE UNIVERSITY OF LIVERPOOL United Kingdom EU contribution No data Address Senate House, Abercromby Square LIVERPOOL See on map Links Website Opens in new window Total cost No data AKVAFORSK, INSTITUTE OF AQUACULTURE RESEARCH AS Norway EU contribution No data Address UMB, Husdyrbygningen 5010 AS See on map Links Website Opens in new window Total cost No data RUSSIAN FEDERAL RESEARCH INSTITUTE OF FISHERIES AND OCEANOGRAPHY Russia EU contribution No data Address V. Krasnoselskaya Str. 17 MOSCOW See on map Links Website Opens in new window Total cost No data FEDERAL CENTER OF FISH GENETICS AND SELECTION (MOSCOW BRANCH) Russia EU contribution No data Address 14 B, Listvennichnaya Alleya MOSCOW See on map Links Website Opens in new window Total cost No data NOFIMA MARIN AS Norway EU contribution No data Address MUNINBAKKEN 9-13 6122 TROMSO See on map Links Website Opens in new window Total cost No data