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In What the How Much Are Individuals Similar the Different? Towards the Measurement of the Individual Susceptibility to Diseases Or Response to Treatments

Project information

Grant agreement ID: 28892

  • Start date

    1 June 2006

  • End date

    31 May 2009

Funded under:

FP6-POLICIES

  • Overall budget:

    € 2 539 450

  • EU contribution

    € 1 700 000

Coordinated by:

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

Objective

With the BioEMERGENCES project, we aim at providing an experimental platform to observe in vivo emergent patterns at various scales and measure their variability between different individuals of the same species. This is a strategy towards the measurement of the individual susceptibility to genetic diseases or response to treatments. Emergent patterns arising at all levels of living organisms are influenced both by the external environment (top-down) and by the internal environment (bottom-up). As a consequence, two living beings are different even if they are two clones of the same species because the history of their coupling with their external environment is different. For these reasons, medicine evolves towards personalised protocols. To make them tangible, we have to be able to achieve the measurement at all organisation levels of the individual response to genetic defects or xenobiotics.

The impossible measurement of individual differences will be tackled in a live vertebrate organism -the zebrafish- that has been largely validated as a powerful model for investigations related to human. Selected emergent phenomena arising at various scales will be recorded and reconstructed to measure the qualitative and quantitative differences between two classes of individuals. Measuring the individual response to a new class of anti-cancer drugs -the DRIL molecules- and the individual susceptibility to holoprosencephaly in a genetically deficient fish population will serve as a testbed for our experimental platform.

The main result expected from BioEMERGENCES is the specification of a European platform to achieve high throughput measurement of individual differences and screening of drugs combinations such as bi or tri-therapies. Such a platform will allow responding t o both the unavoidable scientific question of the construction of a synthetic description of individuals and the future requirement for new drugs in the field of personalized nano-medicine.

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Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Address

3 Rue Michel Ange
Paris

France

Participants (6)

DENALI CONSULTING S.A.

Belgium

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

INSTITUT CURIE

France

SLOVENSKA TECHNICKA UNIVERZITA V BRATISLAVE

Slovakia

UNIVERSIDAD DE MÁLAGA

Spain

UNIVERSITA' DI BOLOGNA UNIVERSITA' DI BOLOGNA

Italy

Project information

Grant agreement ID: 28892

  • Start date

    1 June 2006

  • End date

    31 May 2009

Funded under:

FP6-POLICIES

  • Overall budget:

    € 2 539 450

  • EU contribution

    € 1 700 000

Coordinated by:

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France