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New tools for delivering therapeutic proteins: application to human therapy

Project information

Grant agreement ID: 14320

  • Start date

    1 July 2005

  • End date

    30 June 2009

Funded under:

FP6-MOBILITY

Coordinated by:

UNIVERSITÉ JOSEPH FOURIER, GRENOBLE 1

France

Objective

There is a worldwide pent-up demand for the development of new technologies to allow rapid medical diagnostic and specific human therapy. One of the major challenges now is to develop delivery systems, which are convenient and effective for tackling problems in disease treatments. We have developed two new strategies aiming at producing and delivering biotherapeutic proteins.

The first one is based on the use of polypeptide transduction carriers to directly deliver therapeutic proteins into mammalian tissues and cells. We have recently isolated and characterised two new natural polypeptides transduction carriers, which have the capacity with a high efficiency to directly traverse biological membranes. We anticipate that these membrane permeable proteins will represent a new class of transduction carriers and may have important functions in protein therapy for cancer and infectious diseases.

The second one focused on in vitro protein synthesis technologies for producing recombinant proteins. We have recently demonstrated the effectiveness of a cell-free expression system in production of membrane proteins directly coupled to liposomes. Our technology for producing membrane proteins represents an original and powerful approach to produce immunogenic proteoliposomes fo r the development of new vaccines delivery systems and therapeutic proteoliposomes for human diseases.

The long-term objective of this proposal is to provide new vectors for biologically relevant vaccines and delivery of therapeutic proteins and also, to in crease our potential in therapeutic strategies. These biological vectors will be checked for their transduction properties by testing therapeutic protein candidates on human diseases models. This original approach represents a unique system that would allow increasing the potential in therapeutic strategies for the European academic and pharmaceutical laboratories and will bring out a considerable breakthrough into the worldwide human therapy.

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Coordinator

UNIVERSITÉ JOSEPH FOURIER, GRENOBLE 1

Address

621 Avenue Centrale - Domaine Universitaire
Grenoble

France

Project information

Grant agreement ID: 14320

  • Start date

    1 July 2005

  • End date

    30 June 2009

Funded under:

FP6-MOBILITY

Coordinated by:

UNIVERSITÉ JOSEPH FOURIER, GRENOBLE 1

France