Objetivo There is a worldwide pent-up demand for the development of new technologies to allow rapid medical diagnostic and specific human therapy. One of the major challenges now is to develop delivery systems, which are convenient and effective for tackling problems in disease treatments. We have developed two new strategies aiming at producing and delivering biotherapeutic proteins.The first one is based on the use of polypeptide transduction carriers to directly deliver therapeutic proteins into mammalian tissues and cells. We have recently isolated and characterised two new natural polypeptides transduction carriers, which have the capacity with a high efficiency to directly traverse biological membranes. We anticipate that these membrane permeable proteins will represent a new class of transduction carriers and may have important functions in protein therapy for cancer and infectious diseases.The second one focused on in vitro protein synthesis technologies for producing recombinant proteins. We have recently demonstrated the effectiveness of a cell-free expression system in production of membrane proteins directly coupled to liposomes. Our technology for producing membrane proteins represents an original and powerful approach to produce immunogenic proteoliposomes fo r the development of new vaccines delivery systems and therapeutic proteoliposomes for human diseases.The long-term objective of this proposal is to provide new vectors for biologically relevant vaccines and delivery of therapeutic proteins and also, to in crease our potential in therapeutic strategies. These biological vectors will be checked for their transduction properties by testing therapeutic protein candidates on human diseases models. This original approach represents a unique system that would allow increasing the potential in therapeutic strategies for the European academic and pharmaceutical laboratories and will bring out a considerable breakthrough into the worldwide human therapy. Ámbito científico medical and health sciencesclinical medicineoncologyskin cancermelanomanatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health scienceshealth sciencesinfectious diseasesRNA virusesinfluenzamedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health scienceshealth sciencespublic healthepidemiologymodeling of diseases spread Palabras clave Biotherapeutic proteins delivery vectors membrane proteins protein therapy recombinant proteins therapeutic proteoliposomes vaccines vectors Programa(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Tema(s) MOBILITY-3.1 - Marie Curie Excellence Grants (EXT) Convocatoria de propuestas FP6-2002-MOBILITY-8 Consulte otros proyectos de esta convocatoria Régimen de financiación EXT - Marie Curie actions-Grants for Excellent Teams Coordinador UNIVERSITÉ JOSEPH FOURIER, GRENOBLE 1 Aportación de la UE Sin datos Dirección 621 Avenue Centrale - Domaine Universitaire GRENOBLE Francia Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos
