Cel The proposed research concerns molecular beacon technology in infectious diseases in general and HIV disease in particular. This is a well-timed area with numerous possible applications and where fundamental technologies in biomedical sciences are limiting and novel technologies are increasingly in demand.The first overall goal of this initial research project is to investigate the role of HIV-1 cellular viral load and antiretroviral drug-resistant variants on the antiretroviral treatment of HIV-1-infected individuals by using novel quantitative HIV-1 diagnostic assays. The assays have been previously constructed and evaluated in our laboratory and are based on molecular beacon and allele discriminating real-time PCR technologies that is the primary technology of our laboratory.Our first aim involves investigating the implications of the concentration of HIV-1 DNA in peripheral blood mononuclear cell PBMC) samples ('HIV-1 cellular Viral Load') in predicting the virological response to antiretroviral therapy. In the second aim, we will quantify minor populations of HIV-1 drug resistant strains on mother-to-infant HIV-1 cohorts.The results of the proposed studies will have a direct impact on the clinical care of HIV-1-infected individuals including Cypriot patients. The second goal is to investigate the phylogenic (subtype) distribution and spread of antiretroviral drug-resistance of HIV-1 strains from recent and long-standing patients in Cyprus.It is hoped that the grant support of the Marie Curie International Reintegration Grant will allow the principal investigator to establish a new research laboratory in the University of Cyprus in the best possible conditions and initiate my research activities. Dziedzina nauki medical and health scienceshealth sciencespublic healthepidemiologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health sciencesbasic medicinemedical genetics Program(-y) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Temat(-y) MOBILITY-4.2 - Marie Curie International Reintegration Grants (IRG) Zaproszenie do składania wniosków FP6-2002-MOBILITY-12 Zobacz inne projekty w ramach tego zaproszenia System finansowania IRG - Marie Curie actions-International re-integration grants Koordynator UNIVERSITY OF CYPRUS Wkład UE Brak danych Adres 75 Kallipoleos Avenue 20537 NICOSIA Cypr Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych
