Obiettivo Glioma is the most common tumour of the brain and its most malignant form, glioblastoma multiforme, is virtually not curable. Very little is known about gliomagenesis and progression at the molecular level and not much progress have been achieved in the discovery of new therapies during the last years. Among others, two signalling pathways are very relevant in glioma, the TGFb pathway and the PDGF pathway. TGFb has two differentiated faces in glioma progression. In low-grade glioma, TGFb is an anti-tumorigen ic factor that mediates the inhibition of proliferation. In high-grade glioma, glioblastoma multiforme, TGFb becomes an oncogenic factor that induces proliferation, invasion, angiogenesis and immuno-supression.Another pathway that is important in the genes is of glioma is the PDGF pathway. PDGF and the PDGF receptor are highly expressed in human glioma and PDGF over-expression promotes the formation of glioma in a mouse model. Our preliminary data indicate that at the crossroad of the PDGF and TGFb pathways there is a transcription factor called FoxG1. FoxG1 is the cellular homologue of an avian sarcoma viral oncogene called Qin. FoxG1 is expressed in neuroprogenitors and glioma but not in differentiated cells. FoxG1 inhibits differentiation and promotes proliferation.We hypothesize that FoxG1 promotes the switch of the TGFb action towards its malignant effects and in part mediates PDGF oncogenesis. In order to test this hypothesis we will undertake three approaches: we will study TGFb,PDGF and FoxG1 molecular interactions in a cell culture model using human glioblastoma cell lines. We will assess their role in glioma progression in a mouse glioma model. And, we will support our findings analysing human tumours from the Vall dHebron Hospital tumour bank. This project aims to clarify the molecular mechanisms of gliomagenesis and to help in the finding of new biomarkers and targets for future and more effective therapies. Campo scientifico medical and health sciencesclinical medicineoncology Programma(i) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Argomento(i) MOBILITY-4.2 - Marie Curie International Reintegration Grants (IRG) Invito a presentare proposte FP6-2002-MOBILITY-12 Vedi altri progetti per questo bando Meccanismo di finanziamento IRG - Marie Curie actions-International re-integration grants Coordinatore VALL DHEBRON UNIVERSITY HOSPITAL RESEARCH INSTITUTE Contributo UE Nessun dato Indirizzo Passeig Vall dHebron 119-129 BARCELONA Spagna Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato
