Obiettivo The development of novel technologies of immuno-therapies holds great promise for potential future treatment of hitherto difficult to cure viral diseases and tumours. It is to be anticipated that such technologies will provide the physician with potent novel therapies and will be the basis for the establishment and growth of new biotech SMEs. This proposal suggests therefore to combine research work on natural killer (NK) cell immune defences and therapies, with training in bio-informatics and issues of patent applications and management of the biotech business.The research part will deal with mechanisms of the innate immune defence used to control viral infections and tumours. It will focus on receptors used by NK and some myeloid cells to interact with surf ace structures exposed by virally infected and/or tumour cells. Firstly, it will investigate the mechanisms developed by viruses and tumours to avoid or subvert immune defences. In this respect viruses have evolved a large number of genes, which function to interfere with the expression of ligands that could be used by NK cells to trace infected cells. Similarly, many of the same or related target molecules can be found down regulated in tumour cells. Secondly, we will use the molecules recognized by receptors on NK and myeloid cells to develop technologies to boost immune reactions.This will be done by:i) by specific reagents directing immune cells to the infected/malignant target cells andii) by genetically engineering NK cells to provide them with increased activities.We intend to train the students of this RTN in all techniques of immuno-technology including wider aspects of molecular medicine by enrolling them in the established MD/PhD programs of the respective Universities. An exchange of students between the different partners will be organized to ensure that every participant will be trained at different places. Training in bio-informatics using the NK and leukocyte receptor complexes of the human genome. Campo scientifico social scienceseducational sciencesdidacticsnatural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesbasic medicineimmunologyimmunotherapymedical and health sciencesclinical medicineoncologyleukemia Parole chiave Cytomegalovirus NK-receptors bioinformatics biotech-business biotech-patents Programma(i) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Argomento(i) MOBILITY-1.1 - Marie Curie Research Training Networks (RTN) Invito a presentare proposte FP6-2004-MOBILITY-1 Vedi altri progetti per questo bando Meccanismo di finanziamento RTN - Marie Curie actions-Research Training Networks Coordinatore MEDICAL UNIVERSITY OF VIENNA Contributo UE Nessun dato Indirizzo Spitalgasse 23 VIENNA Austria Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (11) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto AFFIMED THERAPEUTICS AG Germania Contributo UE Nessun dato Indirizzo Technologiepark, Im Neuenheimer Feld 582 HEIDELBERG Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato ANTHONY NOLAN TRUST / NOTTINGHAM TRENT UNIVERSITY Regno Unito Contributo UE Nessun dato Indirizzo Royal Free Hospital, Pond Street, Hampstead LONDON Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato CHANCELLORS MASTERS & SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Regno Unito Contributo UE Nessun dato Indirizzo The Old Schools, Trinity Lane CAMBRIDGE Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato COPENHAGEN BUSINESS SCHOOL Danimarca Contributo UE Nessun dato Indirizzo Solberg Plads 3 FREDERIKSBERG Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato EUROPEAN MOLECULAR BIOLOGY LABORATORY Regno Unito Contributo UE Nessun dato Indirizzo Meyerhofstrasse 1 HEIDELBERG Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato EUROPEAN PATENT ORGANISATION Germania Contributo UE Nessun dato Indirizzo Erhardtstr. 27 MUNICH Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato HEINRICH HEINE UNIVERSITY DÜSSELDORF Germania Contributo UE Nessun dato Indirizzo Moorenstrasse 5 DÜSSELDORF Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato THE HEBREW UNIVERSITY OF JERUSALEM Israele Contributo UE Nessun dato Indirizzo The Authority for Research and Developement, Edmond J. Safra Campus Givat Ram JERUSALEM Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITAT POMPEU FABRA Spagna Contributo UE Nessun dato Indirizzo Plaça de la Mercè, 10-12 BARCELONA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF RIJEKA MEDICAL SCHOOL Croazia Contributo UE Nessun dato Indirizzo Brace Branchetta 20 RIJEKA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato VIENNA UNIVERSITY OF ECONOMICS AND BUSINESS ADMINISTRATION Austria Contributo UE Nessun dato Indirizzo Augasse 2-6 VIENNA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato