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Risk assessment and environmental safety affected by compound bio-availability in multiphase environments

Objective

Bioavailability is mostly considered as a property of a chemical compound. Recent results show bioavailability as result of complex interactions of a compound or a mixture with the affected biota, the environmental matrix, and the respective time scale. New concepts for the assessment of ecotoxicological impacts based on the effect of compounds on a biological receptor do not reflect these results.

Such effects are correlated to the concentrations measured in a given environment without account of the bioavailable amount under that condition. Therefore, present risk assessment strategies for chemicals in the environment ignore system-related bioavailability and thus over-estimate the risks. RAISEBIO will focus on the present gaps in understanding the underlying mechanisms of bioavailability by a new system related interdisciplinary approach. Compound matrix, compound organism, organism matrix interactions and their combined interactions in soil systems and residue formation related issues will be covered by the research in the project.

RAISEBIO will improve the knowledge of bioavailability and facilitate predictive modelling in environmental systems and will foster the awareness of such issues in current and future European strategies of risk assessment and approval of chemicals and generally in environment and health.

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Coordinator

UFZ - UMWELTFORSCHUNGSZENTRUM LEIPZIG - HALLE GMBH

Address

Permoserstrasse 15
Leipzig

Germany

Project information

Grant agreement ID: 20984

  • Start date

    1 September 2006

  • End date

    31 August 2010

Funded under:

FP6-MOBILITY

Coordinated by:

UFZ - UMWELTFORSCHUNGSZENTRUM LEIPZIG - HALLE GMBH

Germany