Kainate receptors and neuronal growth

Projektinformationen

KRANG

ID Finanzhilfevereinbarung: 21348

Startdatum 4 Mai 2006

Enddatum 3 Mai 2008

Finanziert unter

• Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Gesamtkosten € 0,00

EU-Beitrag € 161 314,00

Koordiniert durch

UNIVERSITY OF BRISTOL
United Kingdom

Ziel

This project sets out to employ emergent techniques and state-of-the-art technology to investigate the cellular and molecular mechanisms underlying the trafficking and synaptic expression of the kainate receptor subunit GluR6 in developing hippocampal newer ones. Briefly, a series of chimeras of KAR subunits and new fluorophores including pH-sensitive GFP (pHluorin) and photoactivatable-GFP will be constructed, expressed in neurones by viral infection protocols and imaged using confocal microscopy to determine how kainate receptors behave in living hippocampal neurones and what pathways are involved in their trafficking. This questions are important because kainate receptors in general, and GluR6 in particular, have been implicated in neuronal development an d synapse stabilisation. Therefore, increased understanding of the processes that regulate these subunits will inform work on normal neuronal development and plasticity as well neuropathology associated with certain neurodegenerative conditions such as Al zheimer's disease.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• medical and health sciences › clinical medicine › oncology
• medical and health sciences › basic medicine › neurology › stroke
• natural sciences › physical sciences › optics › microscopy › confocal microscopy

Programm/Programme

• FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Thema/Themen

• MOBILITY-2.3 - Marie Curie Incoming International Fellowships (IIF)

Aufforderung zur Vorschlagseinreichung

FP6-2004-MOBILITY-7
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

IIF - Marie Curie actions-Incoming International Fellowships

Koordinator

UNIVERSITY OF BRISTOL

• EU-Beitrag: Keine Daten
• Adresse: Senate House Tyndall Avenue ; BRISTOL ; Vereinigtes Königreich
• Gesamtkosten: Keine Daten