Objetivo The innate immune system provides the first line of immune defence against infectious diseases and in the fight against cancer. The direct recognition of bacteria, viruses and cancer cells by innate immune cells is crucial for priming of the adaptive immune response and the establishment of immunological memory.Innate immune signalling pathways mediated by Toll-like receptors are quite well studied. Little is known about the activation of additional signalling pathways in innate immunity. This project aims at the identification of novel molecules in innate immune pathways in mammalian cells by functional genomics. The focus will be on signalling pathways in myeloid cells involving the Immunoreceptor Tyrosine-based Activation Motif (ITAM) containing adaptor DAP12 and additional innate immune signalling pathways.These studies will include the identification and investigation of innate immune pathways in response to their natural ligands, bacteria and viruses. Powerful technologies of refined retroviral expression cloning combined with advanced proteomics will be applied to identify novel molecular targets by functional read-outs.The molecules originating from the screens will be validated by gene over-expression and gene knock-down in primary immune cells and in in-vivo mouse models. These studies have the potential to increase the basic knowledge in innate immunity and to identify novel drug targets. Molecular targets for agonistic compounds might be identified to provide new anti-viral and anti-bacterial drugs to fight against emerging infectious diseases.The screens might also discover molecular targets for antagonistic compounds for indications of inflammatory diseases and septic shock syndrome. The scientific expertise of the team leader and excellent facilities at the host organisation including a unit of technology transfer are essential prerequisites for the proposed excellence team 'innate immunity'. Ámbito científico natural sciencesbiological sciencesgeneticsmedical and health scienceshealth sciencesinflammatory diseasesmedical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicineoncology Palabras clave bacteria viruses and cancer drug target identification drug target validation functional genomics infectious disease innate immunity proteomics retroviral library screening septic shock Programa(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Tema(s) MOBILITY-3.1 - Marie Curie Excellence Grants (EXT) Convocatoria de propuestas FP6-2002-MOBILITY-8 Consulte otros proyectos de esta convocatoria Régimen de financiación EXT - Marie Curie actions-Grants for Excellent Teams Coordinador DEUTSCHES KREBSFORSCHUNGSZENTRUM Aportación de la UE Sin datos Dirección Im Neuenheimer Feld 280 HEIDELBERG Alemania Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos
