GlycoGold: Exploration of the nature and potential of Glyco-nano-particles
The Training&Mobility and Design&Innovation WPs and active networking ensure a smooth project workflow. The tasks are assigned to international task forces. The research is timely, because the required techniques have evolved to a point that an integrated multinational approach is viable. Secondly, interest of industries in obtaining this information is high. Thirdly, the necessary overall knowledge to perform the research in a single laboratory does no t exist in Europe, and very few graduates have the integrated knowledge to operate in this area, despite the large demand for them.
The network provides an interdisciplinary training environment for these specialists, where training is offered through:
(i) handson experience,
(ii) summer schools aimed to bridge the knowledge gap between the physical and life sciences,
(iii) short courses, lectures, demonstrations and practical training sessions, and
(iv) activities for individual career development.
Dedicated international and multilingual science promoting activities are scheduled annually aimed at young science students and in particular at high-school pupils.
Johannis P. KAMERLING (Prof.)
ASOCIACION CENTRO DE INVESTIGATIONES COOPERATIVA EN BIOMATERIALES-CIC BIOMAGUNE
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
INSTITUTE OF CHEMISTRY, SLOVAK ACADEMY OF SCIENCES
UNILEVER NEDERLAND BV
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
UNIVERSITY COLLEGE LONDON
UNIVERSITY OF ZAGREB, FACULTY OF PHARMACY AND BIOCHEMISTRY
VALTION TEKNILLINEN TUTKIMUSKESKUS (VTT)
Final Activity Report Summary - GLYCOGOLD (Exploration of the nature and potential of glyco-nano-particles)
The exploration of the potential of gold Glyco-nano-particles (GNPs) has been central in the project. We studied the potential of GNPs as a probe for deepening the understanding of biomolecular interactions and as an instrument to solve biomedical problems. We managed to refine the chemical methods to make tailor made nano-particules where we are now able to include a wide variety of functional molecules to the particle. Functionalised GNPs typically have a metallic core of gold (or of other metals or even semiconductors) covered with multiple spacered carbohydrate ligands. These particles can be tailor made to study and optimise the functioning of the active compound, to include special tags for diagnostic purposes, and to achieve targeted delivery.
The following targets have been pursued.
1 To construct well characterised GNPs and their interacting partners.
2 To explore and apply advanced biophysical characterisation methods for GNPs.
3 To explore and apply in-vitro / ex-vivo / in-vivo biomolecular interaction assays.
4 To deepen the understanding of carbohydrate-protein and carbohydrate-carbohydrate biomolecular interactions.
5 To optimise and innovate the design and construction of GNPs.
6 To explore potential biomolecular applications of GNPs.
7 To integrate the results and to draw conclusions on scope and limitations for the use of GNPs.
Deliverables not available
Publications not available