Signal transduction by Ubiquitination, a matter of location
1. Integrating ubiquitination and signalling at the Endoplasmic Reticulum-Golgi boundaries,
2. Membrane trafficking and signal transduction controlled by ubiquitination,
3. Signalling in and around the nucleus.
The objective of the Network is to train 12 young European scientists in one of the most exciting areas of cell signalling using advanced techniques in molecular and cell biology, and to attain the highest standards of intellectual independence and responsibility. In addition, the Network will educate them in knowledge exploitation and entrepreneurial skills. This will be accomplished by the creation of antedram, and includes rotations through the different laboratories of the Network, post-graduate courses and workshops.
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Ger STROUS (Dr)
BEREICH HUMANMEDIZIN DER GEORG-AUGUST-UNIVERSITAET GOETTINGEN
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
DRUG DISCOVERY FACTORY BV
HET NEDERLANDS KANKER INSTITUUT / ANTONI VAN LEEUWENHOEK HOSPITAL
IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE
INSTYTUT BIOCHEMII I BIOFIZYKI - POLSKIEJ AKADEMII NAUK
MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY.
Grant agreement ID: 34555
1 January 2007
31 December 2010
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Final Activity Report Summary - UBIREGULATORS (Signal Transduction by Ubiquitination, a Matter of Location)
We recruited the fellows well within the time limits, the projects started as planned and all 12 people completed their task. No one left early. In the past 4 years, UbiRegulators worked very well: the research projects were performed as planned, the fellows have developed into mature scientists, and, most importantly, the European spirit became part of their lives.
The most important part of the training program were the UbiRegulator courses. Each of them was special; together, they covered most of the science of the Network. In the five courses the most prominent scientists acted as teachers and not only reported the state-of-the art of their science, they also demonstrated how their own careers evolved to the levels of leaders in their fields. It was clear that our fellows started to take (some of) them as their role-models. Among them was the Nobel prize winner 2004, Aaron Ciechanover, who received the Nobel prize for "the discovery of ubiquitin-mediated protein degradation".
In addition, the course in Lauterbad (Freudenstadt) dealt in part with entrepreneurial and intellectual property issues. The closing meeting was held, 23. - 26.09.2010 in Hirschegg, Kleinwalsertal, Austria and organised by Dieter Wolf, USTUTT: "Ubiquitin and Ubiquitin-Like modifiers in cellular regulation and quality control". Seven fellows presented their projects in style for an international audience of ubiquitin experts. They showed that their training really worked and that they are ready for the next step in their careers. In addition they had the opportunity to get to know new groups in the ubiquitin field enabling them to widen their knowledge and contacts. Extensive discussions on walks in the alpine environment made this meeting very informative and special. Training courses were organised in Utrecht (2007), Stockholm (2007), Amsterdam (2008), Freudenstadt (2008), Cracow (MidTerm, 2008), Jerusalem (with RUBICON, 2010, and the closing meeting in Hirschegg, Kleinwalsertal, Austria.
Frequent personal contact between the coordinator and the principal investigators occurred not only during the regular meetings of UbiRegulators, also within the context of the Network of Excellence Rubicon and on other international conferences. This resulted in a smoothly acting network that was able to meet all contract obligations. Altogether, all 8 PhD students are currently working on the final stages of their theses, while three of the four post-docs are still employed by their initial research institute. For the excellent organisation of the MidTerm Review Meeting in Cracow we owe Dr Teresa Zoladek (IBB PAS). Special thanks also goes to Prof. Dieter Wolf (Stuttgart University) for organising two great meetings: the Freudenstadt meeting and the closing meeting at Soellerhaus. We are very grateful for the excellent administrative work of Marion Bleeker and Joost Warsanis.
Deliverables not available
Publications not available