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Training Network on novel animal models for medical purposes

Training Network on novel animal models for medical purposes

Objective

The overall goal is to develop a complex training program for PhD students on mammalian developmental biology, embryology, stem cell research combined with transgenic technology, genetic reprogramming, laboratory animal science and appropriate micromanipulation, microscopic imaging and molecular biological methods, using real-time PCR, micro-arrays andproteomics. Such training would reduce the fragmentation in the ERA in these areas and would enable the graduates to tackle the complexity of transgenic model and genetic reprogramming research. The research rationale of the project is that model organisms are essential to study the genetic basis of human diseases. Transgenic models, especially genetic knock-out mice catalysed the progress. To continue the advan cement, further sophisticated and refined models are crucially needed to study the genetic basis and manifestations of numerous human diseases. This proposal is aimed to develop new tools for the generation of transgenic laboratory animal models both in mo use and rat for comparative analyses of functional genomics. In the mouse stable embryonic stem cell lines enable gene targeting. However, the lack of such cell lines in most mammalians has so far prevented targeted genetic modifications. This proposal is aimed to use new tools such as nuclear replacement and gene targeting in somatic cells as a technological platform for producing new transgenic models. The aim is to further explore and validate the nuclear replacement system for safety and reliability as a technological platform. Our goal is also to generate the first gene targeted rat models. Relevant issues, such as the role of mitochondrial inheritance, somatic cell gene targeting and standardisation of new genotypes by cryo-preservation will be addresse d. Generation of embryonic stem cell lines from cloned embryos and use of embryonic stem cells for partial reprogramming of somatic cells will be studied, as well.

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Coordinator

MEZOGAZDASAGI BIOTECHNOLOGIAI KUTATOKOZPONT

Address

Szent-Gyorgyi Albert Ut. 4
Godollo

Hungary

Administrative Contact

Andras Janos DINNYES (Prof.)

Participants (11)

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BIOTALENTUM TUDASFEJLESZTO KFT

Hungary

DEN KONGELIGE VETERINAER- OG LANDBOHOEJSKOLE

Denmark

HELMHOLTZ ZENTRUM MÜNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)

Germany

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)

France

INSTITUTE OF ZOOLOGY - CHINESE ACADEMY OF SCIENCES

China

KOBENHAVNS UNIVERSITET

Denmark

ROSLIN INSTITUTE (EDINBURGH)

United Kingdom

THE UNIVERSITY OF EDINBURGH

United Kingdom

THE UNIVERSITY OF NOTTINGHAM

United Kingdom

UNIVERZITA KONSTANTINA FILOSOFA V NITRE

Slovakia

VETERINAERMEDIZINISCHE UNIVERSITAET WIEN

Austria

Project information

Grant agreement ID: 35468

  • Start date

    1 November 2006

  • End date

    31 October 2010

Funded under:

FP6-MOBILITY

  • Overall budget:

    € 1 971 284

  • EU contribution

    € 2 600 000

Coordinated by:

MEZOGAZDASAGI BIOTECHNOLOGIAI KUTATOKOZPONT

Hungary