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The intracellular routes of growth factor signalling from the plasma membrane to the nucleus

The intracellular routes of growth factor signalling from the plasma membrane to the nucleus

Objective

Growth factor receptor signalling controls an enormous variety of biological processes, during all stages of animal development and in all tissues and organs. Its importance for the understanding and treatment of human disease can not be overstated. Internalization and intracellular transport has emerged as an important regulator of signal transduction by growth factor receptors. Two parallel strategies will be used to tackle this paradigm shift and exploit the opportunities laying behind it: 1) a join t research program involving 12 teams at the international forefront of the field with the aim to understand how receptor internalization and intracellular traffic regulate signalling and biological responses in both health and disease. We will address th e functional genomics of receptor endocytosis and intracellular transport, and elucidate the molecular mechanisms by which these processes affect growth factor signalling. We will identify new genes and potential drug targets in the endocytic and intracellular transport pathways. We will build mathematical models that recapitulate receptor endocytosis and signalling in space and time, and devise chemical and genetic strategies to modify cellular responses to growth factor signalling by manipulating intracellular trafficking of receptor complexes. 2) a multidisciplinary training scheme for a cohort of 6 PhD students and 6 postdoctoral fellows from throughout Europe. They will collaborate with at least 2 centres, and participate in 12 specialist Workshops in a addition to network meetings. They will gain hands-on experience in cutting-edge techniques from across cell biology, genetics, chemistry and mathematics, and also be trained in other approaches and professional skills. This will create a community of young scientists for whom thematic and trans-national mobility will be first nature, giving them the opportunity to become future leaders in the field, either as academics or in EU industry.

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Coordinator

KAROLINSKA INSTITUTET

Address

Nobels VäG 5
Stockholm

Sweden

Administrative Contact

Carlos IBANEZ (PROF)

Participants (10)

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WEIZMANN INSTITUTE OF SCIENCE

Israel

KLINIKUM DER JOHANN WOLFGANG VON GOETHE UNIVERSITAET

Germany

MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

Germany

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spain

CANCER RESEARCH UK.

United Kingdom

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Switzerland

UNIVERSITY COLLEGE LONDON.

United Kingdom

SEMMELWEIS EGYETEM

Hungary

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

Germany

OSLO UNIVERSITETSSYKEHUS HF

Norway

Project information

Grant agreement ID: 35528

  • Start date

    1 September 2006

  • End date

    31 August 2010

Funded under:

FP6-MOBILITY

  • Overall budget:

    € 2 349 247

  • EU contribution

    € 2 630 000

Coordinated by:

KAROLINSKA INSTITUTET

Sweden