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Protein Tyrosine Phosphatases: Structure, regulation and biological function

Protein Tyrosine Phosphatases: Structure, regulation and biological function

Objective

A major goal for cell biologists is to understand cellular signal transduction mechanisms, as this leads to comprehension of normal tissue biology and provision of more effective cures for disease. Most signalling pathways rely on reversible phosphorylation of amino acids and phosphotyrosine signalling in particular controls cell proliferation, differentiation and migration, and its dysfunction underlies many diseases. Protein phosphotyrosine is regulated through protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). In contrast to PTK research, which has generated insight into many diseases and provided many drug targets, the PTP field is younger and our understanding of PTP action remains relatively crude.

Nevertheless, several PTP genes have recently been linked to diseases including cancer, diabetes, osteoporosis, hypertension, demyelinating disease and ulcers. Since PTPs now represent an exciting class of enzymes for drug targeting, it is urgent that we obtain a deeper understanding o f the molecular, cellular and tissue functions of these enzymes, under normal and pathologic conditions. The proposed network has scientific, technological and training objectives. We aim to rapidly define PTP structures, substrates and ligands, and define the signalling output of PTPs. We will then aim to relate this to the involvement of PTPs in human disease etiology and progression.

This knowledge can then be exploited ultimately in the development of therapeutics targeted at PTPs enzymes. The PTP field is relatively small and geographically fragmented and a key objective is to bring together groups in Europe and Associate States, to deliver a highly interactive network that is interdisciplinary and intersectorial. This Network will be founded on the principal of effective training for the EU-funded researchers and will offer a unique training platform that will increase critical mass, collaboration and best practice in this field.

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Coordinator

UNIVERSITY COLLEGE LONDON

Address

Gower Street
London

United Kingdom

Administrative Contact

Andrew STOKER (Dr)

Participants (11)

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FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPE FELIPE

Spain

KAROLINSKA INSTITUTET

Sweden

INSTITUTE OF BIOCHEMISTRY OF THE ROMANIAN ACADEMY

Romania

FRIEDRICH-SCHILLER-UNIVERSITAET JENA

Germany

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW

Netherlands

INSTITUT PASTEUR

France

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

MERCK SERONO S.A. - GENEVA

Switzerland

THE UNIVERSITY OF MANCHESTER

United Kingdom

WEIZMANN INSTITUTE OF SCIENCE

Israel

The Chancellor, Masters and Scholars of the University of Oxford

United Kingdom

Project information

Grant agreement ID: 35830

  • Start date

    1 February 2007

  • End date

    31 March 2011

Funded under:

FP6-MOBILITY

Coordinated by:

UNIVERSITY COLLEGE LONDON

United Kingdom