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Transglutaminases: role in pathogenesis, diagnosis and therapy

Project information

Grant agreement ID: 36032

  • Start date

    1 September 2006

  • End date

    31 August 2010

Funded under:

FP6-MOBILITY

Coordinated by:

ASTON UNIVERSITY*

United Kingdom

Objective

TRACKS is a Research and Training Network focussed on the physiological and pathophysiological aspects in humans of a family of enzymes called transglutaminases (TGases). TGases are a widely distributed group of enzymes and have diverse functions in the body such as blood coagulation and wound healing, skin and hair barrier formation, extra-cellular matrix assembly, cell adhesion and intracellular signalling. TGases are drawing increasing interest because of their role in the onset and progression of specific pathologies such as celiac disease and associated autoimmunities, neurological disorders and tissue scarring and fibrosis. In celiac disease, a TG2 is the major autoantigen and is suspected to induce other associated autoimmunites such as diabetes and thyoiditis.

The involvement of TGases in neurodegenerative diseases such as Alzheimer's disease, Huntington's disease and Parkinson disease and in tissue fibrosis and scarring like in diabetic nephropathy, is thought to result from a deregulation of enzyme activity leading to loss of tissue homeostasis and the cross-linking and post translational modification of a number of different proteins. Since TGases are thought to be at the centre of the pathogenesis of these different diseases they are considered an important target both for the development of new diagnostics and the development of new therapeutic agents.

The aim of this network is to bring together key groups in Europe both in academic and industry who are actively working in the field of TGase and associated pathologies. By exchange of ideas, trainees, researchers, materials and the organisation of regular meetings, their objective is to gain a deeper understanding of TGases in these different diseases and in so doing develop new diagnostics and therapeutic approaches for their rapid detection and treatment thus providing a European Research Area in the TGases field with collective benefit and competitive advantage.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

ASTON UNIVERSITY*

Address

Aston Triangle
Birmingham

United Kingdom

Participants (7)

COVALAB SARL

France

DEBRECENI EGYETEM

Hungary

TAMPEREEN YLIOPISTO

Finland

UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA

Italy

UNIVERSITA DEGLI STUDI DI TRIESTE.

Italy

UNIVERSITETET I OSLO

Norway

X-LINK LTD

United Kingdom

Project information

Grant agreement ID: 36032

  • Start date

    1 September 2006

  • End date

    31 August 2010

Funded under:

FP6-MOBILITY

Coordinated by:

ASTON UNIVERSITY*

United Kingdom