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Advanced signal-processing for ultra-fast magnetic resonance Spectroscopic Imaging, and Training

Advanced signal-processing for ultra-fast magnetic resonance Spectroscopic Imaging, and Training

Objective

Magnetic Resonance Spectroscopic Imaging - MRSI - is an emerging, non-invasive modality of Molecular Imaging that opens the way to in vivo mapping of metabolism. It will greatly contribute to combating major diseases (cancer, Alzheimer's disease, multiple sclerosis, etc), monitoring therapy, drug development. Spin-offs: food inspection, materials research. Till today, major obstacles to routine clinical applications of MRSI are
1) Long measurement time, several minutes minimal,
2) Low spatial resolution and low signal-to-noise ratio of metabolic images,
3) Considerable complexity of MRSI processing, analysis, and data visualization,
4) Sparseness of training facilities. Exploiting the strong synergy between signal processing and MR methodology, this proposal aims to pave the way to real-time MRSI. This involves - Cutting-edge MRSI signal-processing algorithms for quantitation and imaging of metabolites.
This includes - A 'Virtual Scanner' based on Quantum Mechanics - Advanced Semiparametric Estimation - Innovative Graphical User-Interfacing - Ultra-fast Data Acquisition at the forefront of MR-methodology. - Innovative e-Training/ToK for young researchers and experts. FAST will contribute to establishing MRSI as non-invasive routine tool in the clinic for combating major diseases. An ultimate goal is MRSI during surgery. An innovative graphical user-interface with web-collaboration will enable interactive communication sessions, with data- and action-sharing, between multiple users. FAST is interdisciplinary and intersectorial and lends itself very well for Training/ToK in all facets of MRSI, with advanced interactive web-based and traditional methods. Partner expertise ranges from medicine to theoretical physics, via biochemistry, chemistry, physics, signal processing, informatics, numerical algebra, and encompasses four Industries. Our joint effort will make MRSI a reliable, ultra-fast, non-invasive, metabolite monitor for the clinic.

Coordinator

UNIVERSITE CLAUDE BERNARD LYON 1

Address

43, Boulevard Du 11 Novembre 1918
Villeurbanne

France

Administrative Contact

Danielle GRAVERON (Dr)

Participants (16)

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THE UNIVERSITY OF MANCHESTER

United Kingdom

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

UNIVERSITAET LEIPZIG

Germany

INSTITUTE FOR LANGUAGE AND SPEECH PROCESSING

Greece

TECHNOLOGICAL EDUCATIONAL INSTITUTE OF CHALDIKA

Greece

UNIVERSITE CATHOLIQUE DE LOUVAIN

Belgium

UNIVERSITAT AUTONOMA DE BARCELONA

Spain

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

USTAV PISTROJOVE TECHNIKY, AKADEMIE VD ESKE REPUBLIKY

Czechia

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Switzerland

PHILIPS MEDICAL SYSTEMS NEDERLAND BV

Netherlands

SIEMENS AG

Germany

SANOFI-AVENTIS DEUSTSCHLAND GMBH

Germany

ALTER SYSTEMS

France

EZUS LYON 1 SA

France

LYON INGÉNIERIE PROJETS

France

Project information

Grant agreement ID: 35801

  • Start date

    1 December 2006

  • End date

    30 November 2010

Funded under:

FP6-MOBILITY

  • Overall budget:

    € 2 554 657

  • EU contribution

    € 2 796 204

Coordinated by:

UNIVERSITE CLAUDE BERNARD LYON 1

France