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Collaborative European action into environmental, nutritional and genetic factors in non-Hodgkin's lymphoma aetiology

Project information

Grant agreement ID: 23103

  • Start date

    1 December 2006

  • End date

    30 November 2008

Funded under:

FP6-FOOD

  • Overall budget:

    € 420 000

  • EU contribution

    € 420 000

Coordinated by:

INTERNATIONAL AGENCY FOR RESEARCH ON CANCER

France

Objective

The incidence and mortality of non-Hodgkin???s lymphoma (NHL) are increasing worldwide. Previous studies have addressed the potential etiologic role of environmental factors and have generated useful hypotheses, including exposure to pesticides, polychlorinated biphenyls (PCB), solvents and ultraviolet (UV) radiation; but the results are not consistent. We propose to develop a network to investigate the role of environmental factors in NHL using an integrated and powerful approach, based on two large-scale NHL studies recently conducted in eight European countries that include over 2,400 cases and a comparable control group. Levels of immunologically active pesticides and PCB will be measured in case and control serum samples to obtain an integrated marker of exposure. DNA samples will be genotyped for polymorphisms related to metabolism of specific environmental agents including pesticides and UV radiation. The immunological effect of occupational exposures will be assessed via the application of a job-exposure matrix developed for a similar project on asthma. The work will be extended to an international collaboration of NHL studies (the InterLymph consortium), which includes additional studies from Europe, North America and Australia, for a total of more than 7,500 NHL cases and controls to investigate the role of environmental and nutritional factors, notably exposure to organochlorines and solvents, on the basis of questionnaire data. We intend to overcome the limitations of previous studies of environmental factors of NHL by (i) using biomarker of exposure to relevant environmental agents, (ii) testing the relevant exposure on large series of cases and controls and (iii) addressing the risk of specific NHL subtypes. We expect our results to be highly relevant for understanding the causes and mechanisms of NHL and for developing rational preventive strategies.

Coordinator

INTERNATIONAL AGENCY FOR RESEARCH ON CANCER

Address

150 Cours Albert Thomas
Lyon

France

Participants (4)

INSTITUT CATALA D'ONCOLOGIA

Spain

DEUTSCHES KREBSFORSCHUNGSZENTRUM

Germany

UNIVERSITY OF CAGLIARI

Italy

UNIVERSITY OF YORK

United Kingdom

Project information

Grant agreement ID: 23103

  • Start date

    1 December 2006

  • End date

    30 November 2008

Funded under:

FP6-FOOD

  • Overall budget:

    € 420 000

  • EU contribution

    € 420 000

Coordinated by:

INTERNATIONAL AGENCY FOR RESEARCH ON CANCER

France