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Molecular factors and mechanisms of transmission and pathogenicity of highly pathogenic Avian Influenza Virus

Objective

The epidemic outbreak of the highly pathogenic avian influenza virus (HPAIV) represents serious health and economic threats. The global dimension of the currently emerging HPAIV highlights an urgent need to increase efforts for international and multidisciplinary research collaboration and the development of new diagnostics, vaccines and drugs. The ultimate objective of the EUROFLU project is to fill the knowledge gaps concerning the molecular factors and mechanisms of HPAIV transmission and pathogenesis.

This objective will be reached through integration of interdisciplinary experimental research approaches and bio-informatics analyses. The STREP has three major aspects. One is to identify, characterize and validate HPAIV-factors that are involved in the re cognition and targeting of the virus to the cellular host receptor, thereby defining host range. Special focus will be put on the viral hemagglutinin protein, which contains the binding site for the sialic-acid containing host cell receptor.

The second is to reveal viral and cellular factors and mechanisms that regulate virus replication within the infected cell and can therefore determine cell tropism and host specificity. Focus will be on virus/host-interactions including viral factors from different HPAI V (H5 and H7, and H5/H7-reassortants) and cellular factors. A third aspect is the use of mouse and chicken models for in vivo analysis of HPAIV infections of mammals and birds to monitor HPAIV-transmission and pathogenicity within organisms. The in vivo characterization of immune responses and investigation of mechanism of neurotropism in mice and chicken after HPAIV-infection will finally allow correlation and verification of findings from the biochemical and molecular works with natural and experimental host species.

Call for proposal

FP6-2005-SSP-5-B-INFLUENZA
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Funding Scheme

STREP - Specific Targeted Research Project
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Coordinator

JUSTUS-LIEBIG UNIVERSITAET
Address
Ludwigstrasse 23
Giessen
Germany

Participants (10)

CENTRE DE RECERCA EN SANITAT ANIMAL
Spain
Address
Campus De La Uab, Edifici Cresa
Bellaterra, Barcelona
FRIEDRICH-LOEFFLER-INSTITUT, FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH
Germany
Address
Paul-ehrlich Str. 28
Tuebingen
GEORG-SPEYER-HAUS - CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT
Germany
Address
Paul-ehrlich-str. 42-44
Frankfurt
IBEXPERTS LTD.
Israel
Address
74 Rambam Street
Raanana
INSTITUTE OF VIROLOGY, SLOVAK ACADEMY OF SCIENCES
Slovakia
Address
Dubravska Cesta 9
Bratislava
RINA NETZWERK RNA-TECHNOLOGIEN GMBH
Germany
Address
Takustrasse 3
Berlin
ROBERT KOCH-INSTITUTE
Germany
Address
Nordufer 20
Berlin
TEL AVIV UNIVERSITY
Israel
Address
Ramat Aviv
Tel Aviv
UNIVERSITY OF IOANNINA
Greece
Address
Panepistimioupoli Dourouti
Ioannina
UNIVERSITAETSKLINIKUM MUENSTER
Germany
Address
Domagkstrasse 5
Muenster