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From molecules to networks: understanding synaptic physiology and pathology of the brain through mouse models

Objective

The involvement of synapses in many neurological diseases - "synaptopathies" - is becoming increasingly apparent in recent years. Yet, despite considerable advances in our understanding of the processes of synaptic transmission and plasticity, much remains to be delineated with respect to the molecular details of the individual steps in these processes. Our aim is to further our understanding of synaptic function using a multi-systems approach, from in vitro cell free systems to in vivo models, taking full advantage of genetic mouse models, particularly those serving as models for synaptic dysfunction in neurological disease. Innovative and state of the art technologies will be applied and further developed, including biochemical, molecular, electrophysiological, and optical tools. We will derive detailed knowledge of molecular machineries that drive synaptic transmission and of mechanisms responsible for various forms of synaptic plasticity. We expect that these studies will provide invaluable insights into synaptic function and dysfunction and their contribution to complex brain functions in health and disease.

Field of science

  • /natural sciences/computer and information sciences/data science/data processing
  • /natural sciences/computer and information sciences/artificial intelligence/computational intelligence

Call for proposal

FP6-2004-LIFESCIHEALTH-5
See other projects for this call

Funding Scheme

IP - Integrated Project

Coordinator

MAX-PLANCK-GESELLSCHAFT ZUR FOEDERUNG DER WISSENSCHAFTEN E.V.
Address
Hofgartenstrasse 8
Muenchen
Germany

Participants (17)

VRIJE UNIVERSITEIT AMSTERDAM
Netherlands
Address
De Boelelaan 1085
Amsterdam
UNIVERSITY HOSPITAL HEIDELBERG
Germany
Address
Im Neuenheimer Feld 672
Heidelberg
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
3 Rue Michel-ange
Paris
ERASMUS MEDICAL CENTER ROTTERDAM
Netherlands
Address
Dr. Molewaterplein 50
1738 Rotterdam
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Gower Street
London
ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE
Switzerland
Address

Lausanne
INSTITUTE OF EXPERIMENTAL MEDICINE, HUNGARIAN ACADEMY OF SCIENCES
Hungary
Address
Szigony Street 43
Budapest
UNIVERSITÀ DEGLI STUDI DI MILANO
Italy
Address
Via Festa Del Perdono 7
Milan
THE HEBREW UNIVERSITY OF JERUSALEM
Israel
Address
The Authority For Research And Development, Edmond J. Safra Campus, Givat Ram
Jerusalem
UNIVERSIDAD DE SEVILLA
Spain
Address
C/ San Fernando Nº 4
Seville
INSTITUTE OF EXPERIMENTAL MEDICINE, ACADEMY OF SCIENCES OF THE CZECH REPUBLIC
Czechia
Address
Videnska 1083
Prague
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
20 Park Crescent
N/A London
INSTITUT PASTEUR
France
Address
25-28, Rue Du Docteur Roux
Paris
AXARON BIOSCIENCE AG
Germany
Address
Inf 515
Heidelberg
SYNAPTIC SYSTEMS GMBH
Germany
Address
Rudolf-wissell Straße 28
Göttingen
FAUST PHARMACEUTICALS
France
Address
Boulevard Sebastien Brandt
Illkirch
SYGNIS BIOSCIENCE GMBH & CO. KG
Germany
Address
Im Neuenheimer Feld 515
Heidelberg