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A multidisciplinary study to identify the genetic and environmental causes of asthma in the European Community

A multidisciplinary study to identify the genetic and environmental causes of asthma in the European Community

Objective

GABRIEL provides an integrated multidisciplinary program of post-genome research. Internationally leading groups will apply knowledge of epidemiology, genetics, genomics, proteomics, bioinformatics, statistics, environmental ecology and immunology into the causes of asthma in the European Community. Exceptional epidemiological and clinical surveys have already been assembled of childhood and adult asthma with inclusive information on environmental factors such as tobacco smoke, air pollution, nutrition, allergen exposure and industrial agents. DNA and serum have been stored for analyses.

This resource of 40,000 subjects will be extended to include severe asthmatics for genomic and proteomic analyses. GABRIEL will comprehensively screen candidate genes and perform whole-genome association studies to identify all important genetic influences on asthma with unmatched power to verify positive findings. The large body of results from the study will be exploited by statistical and bioinformatics groups experienced in handling data of this complexity. GABRIEL will identify all important gene environment interactions underlying asthma in the European Community, and the results will be translated in cellular and genomic models to identify their molecular mechanisms. Microbial exposures in rural farming environments result in a dramatic reduction in the development of asthma, indicating that effective tools for the prevention of asthma can be developed.

The consortium will therefore systematically study rural farming environments. Cellular and genomic models to identify the molecular mechanisms of protective environments will be developed as screens for novel therapeutics and the commercialisation of consortium results. GABRIEL contains a strong and innovative ethical component, which together with involvement of the JRC will ensure integration of the results into the European knowledge base for patient understanding and disease prevention.

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Coordinator

IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

Address

Exhibition Road
London

United Kingdom

Administrative Contact

William COOKSON (Professor)

Participants (36)

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LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

CONSORTIUM NATIONAL DE RECHERCHE EN GENOMIQUE(COMPOSANTE CENTRE NATIONAL DE GENOTYPAGE)

France

JOINT RESEARCH CENTRE

Belgium

KAROLINSKA INSTITUTET

Sweden

FORSCHUNGSZENTRUM BORSTEL

Germany

UNIVERSITAETSKLINIKUM OF ULM

Germany

UNIVERSITY OF BASEL

Switzerland

ST GEORGE'S HOSPITAL MEDICAL SCHOOL

United Kingdom

UTRECHT UNIVERSITY FACULTY OF VETERINARY MEDICINE

Netherlands

CHARITE-UNIVERSITASMEDIZIN BERLIN

Germany

LEIDEN UNIVERSITY MEDICAL CENTRE

Netherlands

UNIVERSITY COLLEGE CORK

Ireland

TNO

Netherlands

RUHR-UNIVERSITY-BOCHUM

Germany

UNIVERSITY OF NATURAL RESOURCES AND APPLIED LIFE SCIENCES

Austria

UNIVERSITE DE FRANCHE-COMTE

France

UNIVERSITY HOSPITAL GRONINGEN

Netherlands

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

WROCLAW MEDICAL UNIVERSITY

Poland

GENEOS LTD

Finland

EMC MICROCOLLECTIONS GMBH

Germany

UNIVERSITY OF AARHUS

Denmark

UNIVERSITY OF BRISTOL

United Kingdom

SURFACE THERAPEUTICS

United Kingdom

HELSINKI UNIVERSITY CENTRAL HOSPITAL

Finland

SIBERIAN STATE MEDICAL UNIVERSITY OF THE FEDERAL AGENCY ON HEALTH CARE AND SOCIAL DEVELOPMENT

Russia

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Germany

UNIVERSITY OF VERONA

Italy

INSTITUTE OF BIOCHEMISTRY AND GENETICS OF UFA SCIENCE CENTRE OF RAS

Russia

INSTITUTE OF MEDICAL GENETICS, TOMSK SCIENTIFIC CENTER OF THE SIBERIAN BRANCH OF RUSSIAN ACADEMY OF MEDICAL SCIENCES

Russia

CHINESE UNIVERSITY OF HONG KONG

Hong Kong

CORPORACION DE PROMOCION UNIVERSITARIA. UNIVERSIDAD SAN FRANCISCO DE QUITO

Ecuador

BCF DIAGNOSTICS LTD

Ireland

COMMISARIAT À L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

France

TERVEYDEN JA HYVINVOINNIN LAITOS - NATIONAL INSTITUTE FOR HEALTH AND WELFARE

Finland

Project information

Grant agreement ID: 18996

  • Start date

    1 March 2006

  • End date

    31 August 2010

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 13 258 334

  • EU contribution

    € 11 327 585

Coordinated by:

IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

United Kingdom