Lipids are central to the regulation and control of cellular function and to disease and lipidomics is beginning to make significant contributions to understanding cellular and pathophysiological processes. Alkyllysophospholipid analogues have recently received much attention due to their antineoplastic, immunomodulatory and antiparasitic properties. The present proposal aims at developing cost effective, reliable and efficient technologies based on solid phase chemistry (SPOS) for the synthesis of ether phospholipid analogues.
Focused libraries will be synthesised for optimisation of structural features of lead compounds produced at the laboratories of the Institute of Organic and Pharmaceutical Chemistry for specific biological applications including antiprotozoal therapeutics and anticancer compounds. In parallel, SPOS will be used to prepare dendrimeric materials and, particularly, dendrimer-modified resins designed to provide increased loading capacity for solid supports. These modified resins will be evaluated for phospholipid solid phase synthesis.
To complement these activities, the use of High-Energy Techniques with microwaves and ultrasound, whose applicability to SPOS is well-documented, will be investigated. By hosting experienced researchers as well as by interacting with the multidisciplinary expertise of the 3 Partner groups, this project aims for transfer of knowledge in these key areas and techniques in order to maintain the momentum of the research of the Host Institute and improve its competitiveness at national and international level, not only in medicinal chemistry but also in its other activities such as the generation of ligands for homogeneous catalysis and of functional organic materials.
The specific knowledge and advanced skills, to be developed through the course of the ToK project, will benefit both basic research and the potential industrial applications. This approach is not applied by other pharmaceutical chemistry groups in Greece.
Call for proposal
See other projects for this call