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The European Mouse Disease Clinic: a distributed phenotyping resource for studying human disease

Objective

As a first step towards a comprehensive functional annotation of the mouse genome, EUMODIC will undertake a primary phenotype assessment of up to 650 mouse mutant lines. In addition, a number of the mutant lines will be subject to a more in depth secondary phenotype assessment.

The EUMODIC consortium is made up of 18 laboratories across Europe who are experts in the field of mouse functional genomics and phenotyping and have a track record of successful collaborative research in EUMORPHIA. The EUMODIC consortium will build on the work in the EUMORPHIA project that delivered a comprehensive database ' EMPReSS - of Standard Operating Procedures (SOPs) that can be used to determine the phenotype of a mouse. EUMODIC has developed a selection of these screens, EMPReSSslim, which is structured for comprehensive, primary, high throughput phenotyping of large numbers of mice.

We will also adopt innovative approaches to the generation and assessment of cohorts of age-matched mutants and controls for phenotyping. Primary phenotype assessment using EMPReSSslim will be undertaken in four large-scale phenotyping centres at the GSF, Germany; ICS, France; MRC Harwell, UK and the Sanger Institute, UK. Mutant lines will be made available from another EU initiative, the EUCOMM (European Conditional Mouse Mutagenesis) project which aims to produce conditional mutations in 20,000 mouse genes.

A distributed network of centres with in depth expertise in a number of phenotyping domains will undertake more complex, secondary phenotyping screens and apply them to a subset of the mice which have shown interesting phenotypes in the primary screen. The partners will also develop technologies to refine EMPReSSslim and improve throughput of mouse phenotyping. A key element will be the continued development of bioinformatics resources to store the phenotype information and link them to existing database resources.

Call for proposal

FP6-2005-LIFESCIHEALTH-6
See other projects for this call

Funding Scheme

IP - Integrated Project

Coordinator

MEDICAL RESEARCH COUNCIL
Address
20 Park Crescent
n/a London
United Kingdom

Participants (16)

HELMHOLTZ ZENTRUM MÜNCHEN, GERMAN RESEARCH CENTER FOR ENVIRONMENTAL HEALTH, GMBH
Germany
Address
Ingolstadter Landstr. 1
Neuherberg
GENOME RESEARCH LTD
United Kingdom
Address
215 Euston Road
London
HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH
Germany
Address
Inhoffenstrasse 7
N/A Braunschweig
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
Address
Piazzale A. Moro 7
Roma
THE UNIVERSITY OF MANCHESTER
United Kingdom
Address
Oxford Road
Manchester
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Address
Meyerhofstrasse 1
Heidelberg
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III
Spain
Address
Melchor Fernandez Almagro, 3
Madrid
ECOLE NORMALE SUPERIEURE DE LYON
France
Address
46, Allee D'italie
Lyon
TEL AVIV UNIVERSITY
Israel
Address
Ramat Aviv
39040 Tel Aviv
UNIVERSITAT AUTONOMA DE BARCELONA
Spain
Address
Campus Universitari S/n
Bellaterra (Cerdanyola Del Valles)
UNIVERSITÉ DE LAUSANNE
Switzerland
Address
Quartier Unil-centre, Bâtiment Unicentre
Lausanne
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
3 Rue Michel Ange
Paris
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Address
The Old Schools, Trinity Lane
Cambridge
FONDAZIONE TELETHON
Italy
Address
Via Guglielmo Saliceto, 5/A
Rome
BIOMEDICAL SCIENCES RESEARCH CENTER 'ALEXANDER FLEMING'
Greece
Address
34, Alexander Fleming Street
74145 Vari 16672
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE - GROUPEMENT D'INTERET ECONOMIQUE
France
Address
1 Rue Laurent Fries
10142 Illkirch