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The European Mouse Disease Clinic: a distributed phenotyping resource for studying human disease

The European Mouse Disease Clinic: a distributed phenotyping resource for studying human disease

Objective

As a first step towards a comprehensive functional annotation of the mouse genome, EUMODIC will undertake a primary phenotype assessment of up to 650 mouse mutant lines. In addition, a number of the mutant lines will be subject to a more in depth secondary phenotype assessment.

The EUMODIC consortium is made up of 18 laboratories across Europe who are experts in the field of mouse functional genomics and phenotyping and have a track record of successful collaborative research in EUMORPHIA. The EUMODIC consortium will build on the work in the EUMORPHIA project that delivered a comprehensive database ' EMPReSS - of Standard Operating Procedures (SOPs) that can be used to determine the phenotype of a mouse. EUMODIC has developed a selection of these screens, EMPReSSslim, which is structured for comprehensive, primary, high throughput phenotyping of large numbers of mice.

We will also adopt innovative approaches to the generation and assessment of cohorts of age-matched mutants and controls for phenotyping. Primary phenotype assessment using EMPReSSslim will be undertaken in four large-scale phenotyping centres at the GSF, Germany; ICS, France; MRC Harwell, UK and the Sanger Institute, UK. Mutant lines will be made available from another EU initiative, the EUCOMM (European Conditional Mouse Mutagenesis) project which aims to produce conditional mutations in 20,000 mouse genes.

A distributed network of centres with in depth expertise in a number of phenotyping domains will undertake more complex, secondary phenotyping screens and apply them to a subset of the mice which have shown interesting phenotypes in the primary screen. The partners will also develop technologies to refine EMPReSSslim and improve throughput of mouse phenotyping. A key element will be the continued development of bioinformatics resources to store the phenotype information and link them to existing database resources.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

MEDICAL RESEARCH COUNCIL

Address

20 Park Crescent
N/A London

United Kingdom

Administrative Contact

Steve BROWN (Professor)

Participants (16)

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HELMHOLTZ ZENTRUM MÜNCHEN, GERMAN RESEARCH CENTER FOR ENVIRONMENTAL HEALTH, GMBH

Germany

GENOME RESEARCH LTD

United Kingdom

HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH

Germany

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

THE UNIVERSITY OF MANCHESTER

United Kingdom

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

Spain

ECOLE NORMALE SUPERIEURE DE LYON

France

TEL AVIV UNIVERSITY

Israel

UNIVERSITAT AUTONOMA DE BARCELONA

Spain

UNIVERSITÉ DE LAUSANNE

Switzerland

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

FONDAZIONE TELETHON

Italy

BIOMEDICAL SCIENCES RESEARCH CENTER 'ALEXANDER FLEMING'

Greece

CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE - GROUPEMENT D'INTERET ECONOMIQUE

France

Project information

Grant agreement ID: 37188

  • Start date

    1 February 2007

  • End date

    31 January 2012

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 18 734 826

  • EU contribution

    € 11 999 832

Coordinated by:

MEDICAL RESEARCH COUNCIL

United Kingdom