Obiettivo Proteases are key molecules in biological systems. They modify numerous proteins by hydrolytic cleavage, thus controlling and executing many physiological processes. Their intricate networks require a tight regulation to prevent fortuitous proteolysis. Where this regulation fails, proteases trigger pathologies such as neurodegeneration, inflammation, and cancer. Many therapeutic approaches are directed towards proteases or their natural inhibitors, already leading to drugs against life threatening diseases.The tight regulation of proteases by posttranslational modifications makes current functional genomics technologies unsuitable to fully establish biological relevance. CAMP will lay the groundwork to study and understand proteases through activity labeling and functional imaging in cells. Specifically, we will investigate the substrate specificity of proteases using large peptide libraries, derive fluorescent labeling molecules from the sequence information gathered, and use these molecules to investigate proteolytic activities in cellular environments. A set of 45 proteases covering four prototypic protease subfamilies has been selected taking into account scientific relevance, structural diversity, and potential socio-economic interest.Given the estimated number of 600 to 1100 proteases in the human genome, our selected set constitutes a significant representation and will establish the feasibility of our approach to address the protease proteome. CAMP's proteases will serve as prototypes to develop novel protease-specific technologies and probes for studying expression and folding, the activity state of proteases and their endogenous interaction partners in vitro and in vivo. The gathered information will be annotated in a public repository. We expect that the derived insights will foster high-throughput approaches and research, leading to new avenues in drug discovery using integrated data on the protease proteome. Campo scientifico natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicinepathology Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LSH-2003-1.1.0-1 - Topics for Specific Targeted Research Project in the area of Fundamental knowledge and basic tools for functional genomics in all organisms Invito a presentare proposte FP6-2004-LIFESCIHEALTH-5 Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore UNIVERSITAT AUTONOMA DE BARCELONA Contributo UE Nessun dato Indirizzo Campus Universitari de Bellaterra BELLATERRA (CERDANYOLA DEL VALLÈS ) Spagna Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (9) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto MAX-PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. // INSTITUTE OF BIOCHEMISTRY Germania Contributo UE Nessun dato Indirizzo Am Klopferspitz 18a MARTINSRIED Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato EUROPEAN MOLECULAR BIOLOGY LABORATORY Germania Contributo UE Nessun dato Indirizzo Meyerhofstrasse 1 HEIDELBERG Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF ZURICH Svizzera Contributo UE Nessun dato Indirizzo Raemistrasse 71 ZURICH Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato JOZEF STEFAN INSTITUTE Slovenia Contributo UE Nessun dato Indirizzo Jamova 39 LJUBLJANA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato SANOFI-AVENTIS DEUTSCHLAND GMBH Germania Contributo UE Nessun dato Indirizzo Industrial Park Hoechst, Building G 879 FRANKFURT AM MAIN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato CARLSBERG RESEARCH CENTER Danimarca Contributo UE Nessun dato Indirizzo Gamle Carlsberg Vej 10 VALBY Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE Regno Unito Contributo UE Nessun dato Indirizzo Exhibition Road LONDON Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spagna Contributo UE Nessun dato Indirizzo C/ Serrano 117 MADRID Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato ARPIDA AS COPENHAGEN Danimarca Contributo UE Nessun dato Indirizzo Vesterbrogade 188 FREDERIKSBERG C, COPENHAGEN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato