CORDIS
EU research results

CORDIS

English EN
European network for the advancement of clinical gene transfer and therapy

European network for the advancement of clinical gene transfer and therapy

Objective

The field of gene therapy has matured and the prospects are exciting and hopeful since some treatments have now been shown to be effective in the clinic. However, precise quality and safety standards for clinical gene transfer have yet to be defined. Defining optimal methods for the production of standard vector systems would pave the way for accelerated development and improved safety. This would be of enormous value to industry, individual investigators and regulators.
The NoE goal is the creation of a European Network for the Advancement of Clinical Gene Transfer and Therapy (CLINIGENE) integrating multidisciplinary research & development in gene therapy and mobilising all major stakeholders involved in the development of gene therapy medicinal products: academia, industry, regulatory bodies, clinics and patients. CLINIGENE will generate platform databases for particular vectors with respect to their safety and efficacy to ensure product manufacturing according to well-defined quality and safety standards in order to accelerate clinical trials. This will be achieved by compiling all available information and then ranking test and control methods by comparison and through validation by expert partners. The JPA comprises
1. Integration activites: sharing facilities, exchange and high-level training of personnel, e-communication, collaboration with the ESGT
2. Research activities: 6 horizontal activities serving integration towards the generation of reference/standard profile data-bases - AAV, gamma-retrovirus, lentivirus, adenovirus, genetically-modified cells & non-viral vectors - & 4 vertical activities defining a path to optimised clinical protocols - quality and efficacy (manufacture), safety (pharm-tox and virus safety); pre-clinical models and novel assessment tools, clinical trials
3. Dissemination activities: training, high-level education, communication (including a web-site with scientific & medical data-bases), management of shared information, IPR.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

ECOLE NORMALE SUPERIEURE DE CACHAN

Address

61 Avenue Du President Wilson
Cachan

France

Administrative Contact

Odile COHEN-HAGUENAUER (Dr)

Participants (42)

Sort alphabetically

Expand all

UNIVERSITY COLLEGE LONDON

United Kingdom

FONDAZIONE TELETHON

Italy

MEDIZINISCHE HOCHSCHULE HANNOVER (HANNOVER MEDICAL SCHOOL)

Germany

UNIVERSITAT AUTONOMA DE BARCELONA

Spain

INSTITUTE OF MOLECULAR GENETICS, ACADEMY OF SCIENCES, CR

Czechia

PAUL-EHRLICH-INSTITUT

Germany

INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA

Portugal

KAROLINSKA INSTITUTET

Sweden

TECHNISCHE UNIVERSITAET MUENCHEN

Germany

HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH

Germany

DEUTSCHES KREBSFORSCHUNGSZENTRUM

Germany

UNIVERSITÄTSKLINIKUM ULM

Germany

GENETHON

France

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES

France

THE HEBREW UNIVERSITY OF JERUSALEM

Israel

FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR

Italy

MAYO CLINIC ROCHESTER

United States

UNIVERSITY OF EASTERN FINLAND

Finland

INNSBRUCK MEDICAL UNIVERSITY

Austria

BIOALLIANCE PHARMA SA

France

BIORELIANCE LTD

United Kingdom

CELLGENIX TECHNOLOGIE TRANSFER GMBH

Germany

CLEAN CELLS

France

EPIXIS

France

GENOSAFE SAS

France

OXFORD BIOMEDICA PLC

United Kingdom

PLASMID FACTORY GMBH & CO. KG

Germany

THERAVIR MANAGEMENT L.P.

Israel

SCIENCE PRATIQUE S.A.

France

INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY

Italy

MAX DELBRÜCK CTR. FOR MOLECULAR MEDICINE

Germany

VRIIJE UNIVERSITEIT BRUSSEL

Belgium

ECBIO - INVESTIGAÇÃO E DESENVOLVIMENTO EM BIOTECNOLOGIA, S.A.

Portugal

OZ BIOSCIENCES SAS

France

ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

France

COMMISSARIAT A L'ENERGIE ATOMIQUE

France

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

Royal Holloway and Bedford New College

United Kingdom

TRANSGENE, S.A.

France

UNIVERSITE DE LAUSANNE

Switzerland

UNIVERSITÄT ZU KÖLN-UNIVERSITÄTSKLINIKUM KÖLN

Germany

Project information

Grant agreement ID: 18933

  • Start date

    1 April 2006

  • End date

    31 October 2011

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 26 225 000

  • EU contribution

    € 12 000 000

Coordinated by:

ECOLE NORMALE SUPERIEURE DE CACHAN

France