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Concerted action on seroconversion to AIDS and death in Europe

Objective

CASCADE was established in 1997 as a collaboration between the investigators of 22 cohorts of persons with well-estimated dates of HIV seroconversion (seroconverters). It is currently a network of epidemiologists, statisticians, virologists and clinicians from lead HIV institutions in 13 European countries, Australia and Canada. Seroconverters are enrolled into the individual cohorts locally and nationally and are typically followed up life-long. CASCADE's main aim is to monitor newly infected individuals, as well as those already enrolled in studies, over the entire duration of HIV infection.

The main premise is that through pooling data we are able to address issues which cannot be reliably addressed from single studies alone. Our main objectives are to: estimate survival expectations and assess changes over time; assess the impact of adverse drug reactions on survival, particularly if therapy is started close to seroconversion, and monitor changes in the cause of death over time; examine any changes in the characteristics of the virus over time; determine the impact of transmitted resistance, virus subtype, and host genetic factors on response to therapy and clinical outcome; characterise the foci of recent HIV epidemics in Eastern Europe; characterise initial disease progression in new epidemic areas; examine the effect of co-infection on HIV disease and response to therapy; and develop new techniques to facilitate the co-ordination of HIV clinical research across European cohorts.

Follow-up data from seroconverters are unique in providing information from an individual's initial contact with HIV as events can, therefore, be related to roughly the same fixed time point in their disease. Seroconverters thus provide a unique opportunity to study HIV throughout its whole infection period and also enable us to examine the characteristics of recently acquired HIV infection in the population and changes over time.

Call for proposal

FP6-2004-LIFESCIHEALTH-5
See other projects for this call

Coordinator

MEDICAL RESEARCH COUNCIL
Address
20 Park Crescent
London
United Kingdom

Participants (24)

UNIVERSIDADE NOVA DE LISBOA - INSTITUTO DE HIGIENE E MEDICINA TROPICAL
Portugal
Address
Rua Da Junqueira, 96
Lisboa
UNIVERSIDAD MIGUEL HERNANDEZ
Spain
Address
Avenida De La Universidad S/n.
Elche
ROBERT KOCH-INSTITUTE
Germany
Address
Nordufer 20
Berlin
ULLEVAL UNIVERSITY HOSPITAL
Norway
Address
Kirkeveiene 166
Oslo
NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS
Greece
Address
Chr. Lada 6
Athens
HOSPICES CANTONAUX - CHUV (CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS)
Switzerland
Address
Rue Du Bugnon 21
Lausanne
HEALTH PROTECTION AGENCY
United Kingdom
Address
7Th Floor, Holborn Gate, 330 High Holborn
London
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
University Offices, Wellington Square
Oxford
SYDDANSK UNIVERSITET
Denmark
Address
Winsloewparken 17
Odense
MUNICIPAL HEALTH SERVICE
Netherlands
Address
Nieuwe Achtergracht 100
Amsterdam
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Gower Street
London
STATENS SERUM INSTITUTE
Denmark
Address
Artillerivej 5
Copenhagen
TARTU ÜLIKOOL
Estonia
Address
Ulikooli 18
Tartu
NATIONAL INSTITUTE OF HYGIENE
Poland
Address
Chocimska 24
Warsaw
SAINT-PETERSBURG PASTEUR INSTITUTE
Russia
Address
14 Mira Street
Saint-petersburg
IMMUNOCLIN LIMITED
United Kingdom
Address
Rowlandson House, 289- 293 Ballards Lane
London
"PERINATAL PREVENTION OF AIDS INITIATIVE" VOLUNTARY SOCIETY
Ukraine
Address
34, Moukachevsky Loan, Apartment 15
Odessa
INSTITUTO DE SALUD CARLOS III
Spain
Address
C/ Sinesio Delgado 6
Madrid
ACADEMIC MEDICAL CENTER AT THE UNIVERSITY OF AMSTERDAM
Netherlands
Address
Meibergdreef 9 1105 Az
Amsterdam
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE INSERM
France
Address
101 Rue De Tolbiac
Paris
ISTITUTO SUPERIORE DI SANITÀ
Italy
Address
Viale Regina Elena, 299
Roma
UNIVERSITÀ DEGLI STUDI DI MILANO
Italy
Address
Via Festa Del Perdono 7
Milan
UNIVERSITÉ BORDEAUX 2
France
Address
146, Rue Léo Saignat
Bordeaux
UNIVERSITÉ CLAUDE BERNARD LYON 1
France
Address
43 Bd Du 11 Novembre 1918
Villeurbanne