Sensor nanoparticles for ions and bio-molecules
The polymer matrix of the nanoparticle does not only provide a selective scaffold for the fluorophore, it also provides a defined microenvironment, in which the binding of the analyte and the concomitant change in fluorescence cannot be compromised by interfering biomolecules (e.g. proteins). The size of the nanoparticles can be tailored to the specific task. Molecularly imprinted analyte-sensitive nanoparticles of larger diameter (300 - 600 nm) may be embedded in tissues whereas small nanoparticles (50 - 300 nm) can be injected directly into living cells. Unlike common indicator dyes, nanoparticles do not bind to proteins or accumulate in certain cell compartments.
This fact makes nanoparticles especially suited for the detection of ions whose detection via fluorescent indicator dyes is still limited. Furthermore, molecularly imprinted nanoparticles can open new ways for the detection of biomolecules that cannot be detected presently via fluorescent indicator dyes. Fluorescent nanoparticles will also be applied in process analysis, for the monitoring of food quality, and for the detection of toxic substances and warfare agents.
UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE
UNIVERSITY OF EAST ANGLIA
Final Activity Report Summary - SNIB (Sensor Nanoparticles for Ions and Biomolecules)
Furthermore, in close cooperation with the Research Training Network NASCENT http://www.nascent.qmul.ac.uk/ and the Intra-European Fellowship NIR-NanoBioSense, core-shell zeolite and silica nanoparticles were developed and combined with new functional indicator dyes to give sensor nanoparticles for nucleotides and saccharides and to give nanomaterials for drug release.
The fellows of the project took part in two scientific workshops organised in Jena, where they presented their results to an international audience, and they participated in the workshop "Advanced Study Course on Optical Chemical Sensors" http://www.ascos.org/ which is an ECTS accredited European initiative to establish an education, discussion and contact platform for young researchers working in the field of optical chemical sensors.
All Marie Curie fellows were immediately integrated into the social life and work environment at the University of Jena, because they were fully supported by the host researchers and by the bureau for research transfer of FSU. The fellows learned new scientific technologies and skills in dissemination and presented their results at international conferences and workshops. The fellows successfully transferred their high scientific experience to the host researchers. After the termination of their research work, all fellows immediately found new employment either in Germany or in their home-countries, based on their experience and excellent scientific reputation in the strongly growing research field of smart nanomaterials.
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