CORDIS
EU research results

CORDIS

English EN

Sensor nanoparticles for ions and bio-molecules

Project information

Grant agreement ID: 29554

  • Start date

    1 August 2006

  • End date

    31 July 2010

Funded under:

FP6-MOBILITY

Coordinated by:

FRIEDRICH-SCHILLER-UNIVERSITAET JENA

Germany

Objective

The task of SNIB is to develop functional nanoparticles that allow the detection of ions (e.g. sodium, potassium, chloride), biomolecules (e.g. transmitter substances, amino acids, saccharides) or drugs and their metabolites in living cells and tissues. Analyte recognition is achieved via fluorescent indicator dyes that are embedded in the matrix of the nanoparticles. Specific binding of the analytes to the fluorophore causes changes in the fluorescence properties (e.g. fluorescence intensity and lifetime).

The polymer matrix of the nanoparticle does not only provide a selective scaffold for the fluorophore, it also provides a defined microenvironment, in which the binding of the analyte and the concomitant change in fluorescence cannot be compromised by interfering biomolecules (e.g. proteins). The size of the nanoparticles can be tailored to the specific task. Molecularly imprinted analyte-sensitive nanoparticles of larger diameter (300 - 600 nm) may be embedded in tissues whereas small nanoparticles (50 - 300 nm) can be injected directly into living cells. Unlike common indicator dyes, nanoparticles do not bind to proteins or accumulate in certain cell compartments.

This fact makes nanoparticles especially suited for the detection of ions whose detection via fluorescent indicator dyes is still limited. Furthermore, molecularly imprinted nanoparticles can open new ways for the detection of biomolecules that cannot be detected presently via fluorescent indicator dyes. Fluorescent nanoparticles will also be applied in process analysis, for the monitoring of food quality, and for the detection of toxic substances and warfare agents.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

FRIEDRICH-SCHILLER-UNIVERSITAET JENA

Address

Fuerstengraben 1
Jena

Germany

Participants (2)

UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE

France

UNIVERSITY OF EAST ANGLIA

United Kingdom

Project information

Grant agreement ID: 29554

  • Start date

    1 August 2006

  • End date

    31 July 2010

Funded under:

FP6-MOBILITY

Coordinated by:

FRIEDRICH-SCHILLER-UNIVERSITAET JENA

Germany