Transfer of knowledge required to understand cross talk between host and pathogen during gastrointestinal infections in humans
Significant expertise exists within the HP Cluster in working with these pathogenic bacteria. However the HP cluster has identified a deficit of methodological knowledge in the area of advanced techniques for the study of host-pathogen interactions. The specific knowledge transfer that will be facilitated by this project will be in two main areas; methodologies for the study of cell signalling events and post-genomic technologies for the study of gene expression within the GI tract. Infections by GI pathogens are a major cause of human suffering and death, both in Europe and throughout the world.
Understanding the molecular interactions that take place between host and pathogen will be central to any long-term strategy for combating the diseases caused by these GI pathogens. The proposed transfer of knowledge will be achieved in a 48 month project, firstly, by seconding 2 existing personnel from the HP Cluster to 2 world-class partner institutions, and secondly, by recruiting 5 Experienced (ER) and 2 More Experienced (MER) researchers.
Outgoing personnel will return to NUI, Galway with an excellent knowledge of state-of-the-art techniques for host-pathogen research, as well as invaluable contacts at the partner institutions. The recruited researchers will work on a research programme at NUI, Galway that is designed by the HP Cluster to maximise the transfer of relevant knowledge to the host institution and its personnel.
NATIONAL UNIVERSITY OF IRELAND, GALWAY
AABO AKADEMI UNIVERSITY
THE UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS
Final Activity Report Summary - GAMIDI (Transfer of knowledge required to understand cross-talk between host and pathogen during gastrointestinal infections in humans)
The successful transfer of skills and molecular technologies has allowed an integration of analysis of host and bacterial responses during the infection process. The acquisition of the multidisciplinary approaches in cell biology, molecular biology, transcriptomics, proteomics and bioinformatics has increased the national and international impact of the research cluster and has acted as a catalyst for developing new international scientific and industrial collaborations from a variety of funding agencies.
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