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From receptor to gene: structures of complexes from signalling pathways linking immunology, neurobiology and cancer

From receptor to gene: structures of complexes from signalling pathways linking immunology, neurobiology and cancer

Objective

SPINE2-COMPLEXES (S2C) builds on SPINE successes (in establishing infrastructure and activity in HTP structural biology across Europe) to attack two of the central objectives of Structural Biology. Firstly, S2C will focus on systems of demonstrated biomedical relevance, almost entirely human proteins (plus some viral mimics). Secondly it will address the functional form of these proteins, complexes, interlinked in human signalling pathways of importance for human health. The S2C team is built upon a core of SPINE laboratories, selected on the basis of their enthusiasm to sign up to the concept of sharing work and pooling protein reagents within the Partnership to accelerate progress through cooperation. The new Partners include excellent young group leaders from the New Member States. Despite dramatic technological advances in HTP protein production there is an urgent need to develop specific technologies appropriate to S2C not covered by other FP6 grants (eg synchrotron technology is largely addressed by BIOXHIT).
Major technology developments will therefore be in protein production, especially HTP methods for eukaryotic expression, including co-expression, through refolding, to library based methods. The human signaling pathways targeted are
i) ubiquitination and de-ubiquitination
ii) cell cycle and apoptosis
iii) synaptogenesis and neuronal signalling
iv) kinases and phosphatases involved in signalling and regulation
v) transcriptional receptors and regulation
vi) innate and acquired immune receptors and inflammation and vii) viral subversion of cellular signalling and immune modulation.
These cellular processes frequently involve the same components and pathways, enhancing opportunities for inter-partner synergies. All Partners have signed up to joint target activity with at least one other Partner. Since S2C builds on SPINE we will be able to implement a transparent and effective management system, minimising the start-up time.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

Address

University Offices, Wellington Square
Oxford

United Kingdom

Administrative Contact

David Ian STUART (Professor)

Participants (17)

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WEIZMANN INSTITUTE OF SCIENCE

Israel

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE - GROUPEMENT D'INTERET ECONOMIQUE

France

KAROLINSKA INSTITUTET

Sweden

UNIVERSITY OF YORK

United Kingdom

UNIVERSITEIT UTRECHT, FACULTY OF SCIENCES, DEPT. OF CHEMISTRY

Netherlands

THE NETHERLANDS CANCER INSTITUTE - ANTONI VAN LEEUWENHOEK HOSPITAL

Netherlands

CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLOPROTEINE PARAMAGNETICHE

Italy

EUROPEAN SYNCHROTRON RADIATION FACILITY

France

MAX DELBRUCK CENTER FOR MOLECULAR MEDICINE

Germany

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spain

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

UNIVERSITE PARIS-SUD

France

MTA ENZIMOLOGIAI KUTATOINTEZET

Hungary

USTAV MAKROMOLEKULARNI CHEMIE AKADEMIE VED CESKE REPUBLIKY

Czechia

DOMAINEX LTD

United Kingdom

INSTITUTO DE TECHNOLOGIA QUÍMICA E BIOLÓGICA

Portugal

Project information

Grant agreement ID: 31220

  • Start date

    1 July 2006

  • End date

    30 June 2010

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 13 172 500

  • EU contribution

    € 12 000 000

Coordinated by:

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom