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Neonatal estimation of brain damage risk and identification of Neuroprotectants

Project information

Grant agreement ID: 36534

  • Start date

    15 October 2006

  • End date

    14 October 2010

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 4 960 567

  • EU contribution

    € 3 299 809

Coordinated by:

MEDIZINISCHE HOCHSCHULE HANNOVER

Germany

Objective

NEOBRAIN is a project that brings together SMEs, industry and academic groups devoted to the diagnosis, management, and neuroprotection in newborns with perinatal brain damage. The focus of the project is the prevention of hypoxic-ischemic and inflammation-associated brain damage mainly observed in preterm newborns.
The objectives of the project are
1. to generate marker profiles of damage in multiple animal models and in human preterm infants using genomic/genetic, proteomic, and metabolomic approaches, as well as imaging and electrophysiologic modalities;
2. to develop neuroprotective strategies by identifying candidate molecules for intervention using such markers and molecules in animals;
3. to implement a clinical platform for an observational clinical epidemiologic study in human infants designed to contribute to objective #1 above and to transfer insights gained in objectives #1 and #2 from the animal to the human level;
4. to prepare for drug testing by using the project structure as a clinical platform for initial steps in clinical testing of interventions discovered.
We further envision developing the clinical platform in a fashion so it can serve as the basis for a subsequent large scale pan-European perinatal neuroprotective research initiative (Euro-Neo-Net, EURAIBI) that will enable us in the future to conduct additional clinical studies building upon the knowledge gained in NEOBRAIN.

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Coordinator

MEDIZINISCHE HOCHSCHULE HANNOVER

Address

Carl-Neuberg-Str. 1
30623 Hannover

Germany

Participants (17)

BIOCRATES LIFE SCIENCES GMBH

Austria

BIOANALYT GMBH

Germany

THERAPTOSIS S.A.

France

NOSCIRA S.A.

Spain

UNIVERSITY MEDICAL CENTER UTRECHT

Netherlands

GÖTEBORGS UNIVERSITET

Sweden

CHARITÉ, UNIVERSITÄTSMEDIZIN BERLIN

Germany

LUNDS UNIVERSITET

Sweden

MEDIZINISCHE UNIVERSITÄT INNSBRUCK

Austria

UPPSALA UNIVERSITET

Sweden

FONDAZIONE I.R.C.C.S OSPEDALE MAGGIORE POLICLINICO MA.RE.

Italy

UNIVERSITÄT DUISBURG-ESSEN

Germany

CHIESI FARMACEUTICI S.P.A

Italy

NATUS MEDICAL INCORPORATED

United States

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

UNIVERSITA DEGLI STUDI DI SIENA

Italy

UNIVERSITE DE GENEVE

Switzerland

Project information

Grant agreement ID: 36534

  • Start date

    15 October 2006

  • End date

    14 October 2010

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 4 960 567

  • EU contribution

    € 3 299 809

Coordinated by:

MEDIZINISCHE HOCHSCHULE HANNOVER

Germany