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Integrated genomics, clinical research and care in hypertension

Objective

The InGenious HyperCare Network of Excellence's goal is that of integrating complementary but still fragmented experience in the mechanisms of blood pressure control and hypertension development, in phenotyping initiation and progression of organ damage and exploring genetics, genomics and proteomics of proneness to hypertension and hypertension-related cardiovascular disease. A better prevention of hypertension and its cardiovascular consequences is an essential public health goal in Europe, where cardiovascular diseases are the major cause of mortality and morbility. The Network plans to integrate the research efforts of 31 research teams (including a SME) and 1 SME experienced in EC project management. A powerful instrument of integration will be the Programme of Joint Research Activities. A first group of research packages will be addressed to Mechanomics of Hypertension, i.e. identifying genetic, genomic and proteomic markers of disturbances in the major mechanisms (autonomic control, inflammation and oxidative stress, sodium handling) controlling blood pressure, as indicators of the risk of becoming hypertensive.
The second group of research packages will be addressed to Mechanomics of Hypertension-Related Diseases, i.e. identifying the genetic, genomic and proteomic markers of the risk of developing a hypertension-related event (stroke, renal dysfunction, heart failure). Through these activities the Network will build up large integrated platforms of common phenotypes, genotypes and proteomic data in hypertensives, and assemble unique sets of comprehensive databases. Spreading of excellence beyond the Network will be done with the support of the European Society of Hypertension.
The activity of the Network will continue after end of the EC funding, with the objective of contributing better diagnostic tools to identify subjects prone to hypertension, and patients prone to hypertension complications, with obvious benefits for health care in Europe.

Field of science

  • /medical and health sciences/health sciences/public and environmental health
  • /natural sciences/biological sciences/genetics and heredity
  • /medical and health sciences/basic medicine/neurology/stroke
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics
  • /social sciences/sociology/demography/mortality
  • /medical and health sciences/clinical medicine/cardiology/cardiovascular diseases
  • /natural sciences/chemical sciences/inorganic chemistry/inorganic compounds

Call for proposal

FP6-2005-LIFESCIHEALTH-6
See other projects for this call

Funding Scheme

NoE - Network of Excellence

Coordinator

ISTITUTO AUXOLOGICO ITALIANO
Address
Via Ludovico Ariosto 13
Milan
Italy

Participants (32)

UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
Italy
Address
Piazza Dell' Ateneo Nuovo 1
Milano
CENTRE HOSPITALIER UNIVERSITAIRE DE NANCY
France
Address
29 Avenue Du Marechal De Lattre De Tassigny
60034 Nancy
UNIVERSITY OF GLASGOW
United Kingdom
Address
University Avenue
Glasgow
UNIVERSITY OF MANCHESTER
United Kingdom
Address
Oxford Road
Manchester
UNIVERSITY OF LEICESTER
United Kingdom
Address
University Road
Leicester
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Address
Oude Markt 13
Leuven
UNIVERSITEIT MAASTRICHT
Netherlands
Address
Universiteitssingel 50
616 Maastricht
CHARITÉ-UNIVERSITÄTSMEDIZIN BERLIN
Germany
Address
Schumann Str. 20-21
Berlin
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
Address
Carl-neuberg-strasse 1
30623 Hannover
WESTFÄLISCHE WILHELMS UNIVERSITÄT
Germany
Address
Schlossplatz 2
Muenster
FUNDACION DE INVESTIGACION DEL HOSPITAL CLINICO UNIVERSITARIO OF VALENCIA
Spain
Address
Avenida Blasco Ibañez, 17
Valencia
FUNDACIÓN PARA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO 12 DE OCTUBRE
Spain
Address
Av. Córdoba S/n
Madrid
LUNDS UNIVERSITET
Sweden
Address
Paradisgatan 5C
117 Lund
HELSINGIN YLIOPISTO
Finland
Address
Yliopistonkatu 4
Helsinki
MEDICAL UNIVERSITY OF GDANSK
Poland
Address
Marii Sklodowskiej-curie 3A
Gdansk
JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE
Poland
Address
Sw. Anny 12
Krakow
INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE
Czechia
Address
Videnska 1958/9
Prague
CHARLES UNIVERSITY IN PRAGUE
Czechia
Address
Ovocny Trh 5
Prague
MOSAIQUES DIAGNOSTICS GMBH
Germany
Address
Mellendorfer Str. 7-9
Hannover
HOSPICES CANTONAUX
Switzerland
Address
Rue Du Bugnon 21
Lausanne
INSTITUTE OF INTERNAL MEDICINE, SIBERIAN BRANCH OF RUSSIA ACADEMY OF MEDICAL SCIENCES
Russia
Address
St. B. Bogatkova, 175/1
Novosibirsk
SHANGHAI INSTITUTE OF HYPERTENSION
China
Address
Ruijin 2Nd Road 197
Shanghai
CF CONSULTING FINANZIAMENTI UNIONE EUROPEA S.R.L.
Italy
Address
Via Giuseppe Mussi 1
Milano
THOMAYER UNIVERSITY HOSPITAL
Czechia
Address
Videnska 800
Prague
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA
Spain
Address
Edificio Cima Avenida Pio Xii, 55
Pamplona
HOSPITAL CLINIC Y PROVINCIAL DE BARCELONA
Spain
Address
Calle Villarroel 170
Barcelona
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
101 Rue De Tolbiac
Paris
UNIVERSITA DEGLI STUDI DI BRESCIA
Italy
Address
Via Gramsci, 17
Brescia
UNIVERSITA DEGLI STUDI DI MILANO
Italy
Address
Via Festa Del Perdono 7
Milano
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
Address
Via 8 Febbraio, 2
Padova
UNIVERSITA DEGLI STUDI DI ROMA "LA SAPIENZA"
Italy
Address
Piazzale Aldo Moro 5
Rome
UNIVERSITA VITA SALUTE SAN RAFFAELE
Italy
Address
Via Olgettina, 58
Milan