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Integrated genomics, clinical research and care in hypertension

Integrated genomics, clinical research and care in hypertension

Objective

The InGenious HyperCare Network of Excellence's goal is that of integrating complementary but still fragmented experience in the mechanisms of blood pressure control and hypertension development, in phenotyping initiation and progression of organ damage and exploring genetics, genomics and proteomics of proneness to hypertension and hypertension-related cardiovascular disease. A better prevention of hypertension and its cardiovascular consequences is an essential public health goal in Europe, where cardiovascular diseases are the major cause of mortality and morbility. The Network plans to integrate the research efforts of 31 research teams (including a SME) and 1 SME experienced in EC project management. A powerful instrument of integration will be the Programme of Joint Research Activities. A first group of research packages will be addressed to Mechanomics of Hypertension, i.e. identifying genetic, genomic and proteomic markers of disturbances in the major mechanisms (autonomic control, inflammation and oxidative stress, sodium handling) controlling blood pressure, as indicators of the risk of becoming hypertensive.
The second group of research packages will be addressed to Mechanomics of Hypertension-Related Diseases, i.e. identifying the genetic, genomic and proteomic markers of the risk of developing a hypertension-related event (stroke, renal dysfunction, heart failure). Through these activities the Network will build up large integrated platforms of common phenotypes, genotypes and proteomic data in hypertensives, and assemble unique sets of comprehensive databases. Spreading of excellence beyond the Network will be done with the support of the European Society of Hypertension.
The activity of the Network will continue after end of the EC funding, with the objective of contributing better diagnostic tools to identify subjects prone to hypertension, and patients prone to hypertension complications, with obvious benefits for health care in Europe.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

ISTITUTO AUXOLOGICO ITALIANO

Address

Via Ludovico Ariosto 13
Milan

Italy

Administrative Contact

Alberto ZANCHETTI (Prof.)

Participants (32)

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UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA

Italy

CENTRE HOSPITALIER UNIVERSITAIRE DE NANCY

France

UNIVERSITY OF GLASGOW

United Kingdom

UNIVERSITY OF MANCHESTER

United Kingdom

UNIVERSITY OF LEICESTER

United Kingdom

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

UNIVERSITEIT MAASTRICHT

Netherlands

CHARITÉ-UNIVERSITÄTSMEDIZIN BERLIN

Germany

MEDIZINISCHE HOCHSCHULE HANNOVER

Germany

WESTFÄLISCHE WILHELMS UNIVERSITÄT

Germany

FUNDACION DE INVESTIGACION DEL HOSPITAL CLINICO UNIVERSITARIO OF VALENCIA

Spain

FUNDACIÓN PARA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO 12 DE OCTUBRE

Spain

LUNDS UNIVERSITET

Sweden

HELSINGIN YLIOPISTO

Finland

MEDICAL UNIVERSITY OF GDANSK

Poland

JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE

Poland

INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE

Czechia

CHARLES UNIVERSITY IN PRAGUE

Czechia

MOSAIQUES DIAGNOSTICS GMBH

Germany

HOSPICES CANTONAUX

Switzerland

INSTITUTE OF INTERNAL MEDICINE, SIBERIAN BRANCH OF RUSSIA ACADEMY OF MEDICAL SCIENCES

Russia

SHANGHAI INSTITUTE OF HYPERTENSION

China

CF CONSULTING FINANZIAMENTI UNIONE EUROPEA S.R.L.

Italy

THOMAYER UNIVERSITY HOSPITAL

Czechia

FUNDACION PARA LA INVESTIGACION MEDICA APLICADA

Spain

HOSPITAL CLINIC Y PROVINCIAL DE BARCELONA

Spain

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

UNIVERSITA DEGLI STUDI DI BRESCIA

Italy

UNIVERSITA DEGLI STUDI DI MILANO

Italy

UNIVERSITA DEGLI STUDI DI PADOVA

Italy

UNIVERSITA DEGLI STUDI DI ROMA "LA SAPIENZA"

Italy

UNIVERSITA VITA SALUTE SAN RAFFAELE

Italy

Project information

Grant agreement ID: 37093

  • Start date

    1 November 2006

  • End date

    31 January 2011

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 18 199 947

  • EU contribution

    € 10 000 000

Coordinated by:

ISTITUTO AUXOLOGICO ITALIANO

Italy