Cel Major diseases including cardiovascular and renal diseases, diabetes mellitus, obesity, diseases of the immune system, cancer and neurological disorders are caused or are associated with disturbances of compartmentalization cAMP signalling networks. Key players in cAMP signalling are adenylyl cyclases (AC) synthesizing cAMP, phosphodiesterases (PDE) hydrolysing it, and A-kinase anchoring proteins (AKAP) tethering protein kinase A (PKA), the principal effector of cAMP, to cellular compartments. In a multidisciplinary approach based on postgenomic research, we will use established and novel cell lines to identify small 'druggable' therapeutic molecules derived from small molecule libraries which i.) displace PKA, AKAPs and PDEs from their cognate intracellular location and ii.) disrupt protein-protein interactions involving ACs, PDEs, AKAPs and PKA in cellular disease models. The disease models represent cardiovascular diseases, nephrogenic diabetes insipidus (NDI), asthma, chronic obstructive pulmonary disease (COPD), AIDS, obesity, and schizophrenia. Screening of compound libraries will be performed in living cells and in vitro with purified components of the cAMP signalling system. We aim to identify the molecular targets of small molecules using established and to be developed tools and bioassays. Cell signature responses to challenges with small molecules will be defined in order to gain mechanistic insight into the effects on the disease phenotypes and to anticipate side effects of identified substances. The small molecules will be valuable tools to investigate compartmentalised cAMP signalling. Moreover, this approach may lead to alternative strategies for the treatment of diseases associated with altered cAMP signalling that are not addressed effectively by conventional pharmacotherapy.' Dziedzina nauki natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesclinical medicineendocrinologydiabetesmedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesclinical medicinepsychiatryschizophreniamedical and health scienceshealth sciencesnutritionobesity Program(-y) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) LSH-2005-1.2.5-3 - Use of cell lines to define new bioassays for the identification of therapeutic bio-molecules (especially orientated towards small and medium sized companies) Zaproszenie do składania wniosków FP6-2005-LIFESCIHEALTH-6 Zobacz inne projekty w ramach tego zaproszenia System finansowania STREP - Specific Targeted Research Project Koordynator FORSCHUNGSVERBUND BERLIN E.V. / FORSCHUNGSINSTITUT FÜR MOLEKULARE PHARMAKOLOGIE Wkład UE Brak danych Adres Rudower Chaussee 17 BERLIN Niemcy Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (8) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko UNIVERSITAET KASSEL Niemcy Wkład UE Brak danych Adres Moenchebergstrasse 19 KASSEL Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITY OF OSLO Norwegia Wkład UE Brak danych Adres Problemveien 7 OSLO Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych FONDAZIONE TELETHON Włochy Wkład UE Brak danych Adres Via Guglielmo Saliceto 5 ROMA Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITY OF GLASGOW Zjednoczone Królestwo Wkład UE Brak danych Adres University Avenue GLASGOW Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych BIAFFIN GMBH & CO KG Niemcy Wkład UE Brak danych Adres AVZ 2, Heinrich-Plett-Str. 40 KASSEL Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych LAURAS AS Norwegia Wkład UE Brak danych Adres Gaustadalleen 21 OSLO Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych BIOLOG LIFE SCIENCE INSTITUTE, FORSCHUNGSLABOR UND BIOCHEMICA-VERTRIEB GMBH Niemcy Wkład UE Brak danych Adres Flughafendamm 9a BREMEN Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych GÖTEBORGS UNIVERSITET Szwecja Wkład UE Brak danych Adres Vasaparken GÖTEBORG Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych