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Bio-imaging with smart functional nanoparticles

Objective

The overall objective is the development of ultrasensitive bio-imaging techniques based on novel multifunctional nanoparticles (NPs) with tailored optical and magnetic properties for visualizing complex cellular structures, receptors, tumour cells and tissues. True innovation rests on the capability to combine the preparation of 'ad-hoc' NPs, having different properties and functions, with the development of advanced bio-imaging techniques. The expected improvements of labeling cells and cellular structures with tailored NPs are sensitivity, speed and specificity in the visualization of biological systems. We plan the development of stable colloidal solutions containing non-cyto-toxic, colloidally stable Si-based NPs properly functionalized on the surface in order to improve and tune their optical properties and increase their selectivity in specific biological targets. These NPs will be employed, in cooperation with two SMEs, for the development of optical bio-imaging techniques aiming at: (i) understanding how the genome instructs and orchestrates the functions of cells, organs and organisms; (ii) whole-cell labelling for cell or pathogen detection, cell tracking, cell sorting and cell lineage studies; (iii) optical imaging of tumour cells for early cancer diagnostics. A further task concerns the development of stable colloids of non-toxic, non-immunogenic NPs with: (i) high magnetization, so that NP can be moved in the blood and accumulated in the target organ, (ii) particle size small enough to remain in circulation after injection (iii) narrow size distribution for differential uptake of various tissues. The aim is the development of marketable, well tolerated, highly efficient, specific and economically viable contrast agents for the detection and characterization of complex tumour and/or inflammatory lesions in Magnetic Resonance Imaging, in collaboration with our industrial partner'.

Field of science

  • /engineering and technology/medical engineering/diagnostic imaging/magnetic resonance imaging

Call for proposal

FP6-2005-LIFESCIHEALTH-6
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Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE
Address
Lungotevere Grande Ammiraglio Thaon Di Revel 76
Roma
Italy

Participants (12)

COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
Address
25 Rue Leblanc
Paris
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
C/ Serrano Nº 117
Madrid
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
Address
Avda. Complutense S/n
Madrid
MAX PLANCK GESELLSCHAFT
Germany
Address
Hofgartenstr. 8
101062 Muenchen
UNIVERSITA' DI MILANO-BICOCCA
Italy
Address
Piazza Dell'ateneo Nuovo 1
Milano
GUERBET
France
Address
15 Rue Des Vanesses
Villepinte
GENERAL PHYSICS INSTITUTE
Russia
Address
Vavilov St. 38
Moscow
ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG
Germany
Address
Fahnenberglatz
Freiburg
NANOVECTOR SRL
Italy
Address
Via Livorno, 60
Torino
TILL PHOTONICS GMBH
Germany
Address
Lochhamer Schlag 19
Gräfelfing
INSTITUL NATIONAL PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI
Romania
Address
409, Atomistilor Str
MG-36 Bucharest
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
Address
Via 8 Febbraio 2
Padova