The aim of the work is to manufacture novel biomaterials for wound and burns healing and tissue regeneration and characterise their mechanical, physical and physicochemical properties and evaluate their biocompatibility and performance in the required applications. In this project natural and natural/synthetic polymer hydrogels produced by cryopolymerisation will be used to design new materials for tissue regeneration. The existing know how in polymer chemistry, synthesis of activated carbons, protein biochemistry, cell biology and manufacturing of biomaterials, owned by the academic and industrial partners involved in this project, will be combined in order to develop and manufacture novel materials for efficient treatment of wounds and burns and with a potential for wider use in tissue scaffolding and regenerative medicine.
The objectives of the project are:
(i) to develop a new technology for production of super-macroporous polymer cryogels for wound healing and tissue regeneration;
(ii) to produce a number of biopolymer cryogels and evaluate their mechanical, physical and physicochemical properties;
(iii) to design a wound healing material based on polymer cryogels with incorporated activated carbon;
(iv) to design a composite polymer cryogel/activated carbon fibre wound dressing;
(v) to evaluate in vitro biocompatibility of the materials in (i)-(iv);
(vi) to test performance of the materials in (i)-(iv) on advanced 3D skin models;
(vii) to assess the potential of the materials in (i,ii) for cell growth and tissue regeneration.
These objectives will be achieved through the knowledge transfer activities between academic, medical and industrial partners involved in this project.
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