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A biological nanoactuator as a molecular switch for biosensing

Objective

We seek to provide Europe with a major time advantage over their main international competitors by developing a bionanotechnological device that can be used as a nanoactuator/biosensor, which also provides a novel interface between the Biological and Silicon Worlds. The time advantage is provided by 'picking up' the highly successful Mol Switch Project (IST-2001-38036), in which we were able to show that biological molecular motors could be used as bio-nanoactuators. However, this project will push the frontiers of knowledge and skill by developing a useful generic biosensor/nanoactuator device.

The device will be assembled in a series of stages using independent Modules that each incorporate new technology, or, expand the frontiers of existing technology. A prototype integrated biosensor will be built around this nanoactuator, incorporating the proposed Modules. The switching device within this nanoactuator is provided by a moving magnetic particle, attached to the DNA that is translocated (or 'pulled') by the motor, and a suitable electronic sensor that detects this movement. Integration of these individual components into a single Module will provide a major step forward in the design of Lab-on-a-Chip technology. Therefore, we will seek to develop a microfluidics system that will allow us to incorporate the electronic sensor into a chip-based device.

The project will also focus on the precise location and self-assembly of these motors and their DNA substrates within the microfluidics system to be used. The project will involve partners who will focus on the further development of the electronic sensor. We know of no other bionanotechnological device, which incorporates biological molecular motors to produce moving parts, that is as far advanced as this project offers and, therefore, we believe the project will provide the EU with a significant advance in this area.

Call for proposal

FP6-2005-NEST-PATH
See other projects for this call

Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

UNIVERSITY OF PORTSMOUTH
Address
University House Winston Churchill Avenue
Portsmouth
United Kingdom

Participants (6)

NPL MANAGEMENT LTD.
United Kingdom
Address
Hampton Road
Teddington
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
3 Rue Michel Ange
Paris
TECHNISCHE UNIVERSITEIT DELFT
Netherlands
Address
Julianalaan 134
Delft
INSTITUTE OF MICROBIOLOGY, ACADEMY OF SCIENCES OF THE CZECH REPUBLIC
Czechia
Address
Vídenská 1083
Prague 4
SWISS FEDERAL LABORATORIES FOR MATERIALS TESTING AND RESEARCH
Switzerland
Address
Ueberlandstrasse 129
Duebendorf
INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES PARA OS MICROSISTEMAS E NANOTECNOLOGIAS
Portugal
Address
Rua Alves Redol 9
Lisboa