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Global approach to brain activity: from cognition to disease

Global approach to brain activity: from cognition to disease

Objective

Synchronization is a ubiquitous phenomenon in Nature, and has been considered as one of the engines of life in complex biological systems. Its study has originated new fundamental insights and analysis tools in both local and global dynamical models stemming from divergent disciplines. This proposal aims at determining the functional role of normal and aberrant synchronization mechanisms in the emergence of higher cerebral functions in health and disease, by using tools borrowed from nonlinear dynamics and complexity theory.

Specifically, the present proposal addresses the phenomenon of neuronal synchronization, at a wide range of spatial scales, as a major orchestrator of brain integration processes. To that end, it is necessary to understand how local and long-range interactions scale-up to a global activity in the brain. To accomplish this goal, we will recollect and analyze collective brain responses (multichannel-EEG, intracranial EEG, magnetoencephalographic recordings and local field potentials) and single-neuron activity under different normal and abnormal physiological conditions: from cognitive performance (sensory processing, attention, and memory in humans and non-human primates) to pathological mechanisms underlying Alzheimer's disease and epilepsy.

We will apply linear and nonlinear methods, as well as tools from stochastic analysis and from the theories of complex networks and delayed dynamical systems. Such approaches have proven to be very useful in the characterization of complex systems in generic models, and now will be applied for a better understanding of how higher cerebral functions arise in the normal brain. Results from this approach are expected to contribute in the early diagnosis of Alzheimer's disease and in the anticipation of epileptic seizures.

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Coordinator

UNIVERSITAT POLITÈCNICA DE CATALUNYA

Address

Carrer Jordi Girona, 31
Barcelona

Spain

Administrative Contact

Jordi GARCIA-OJALVO (Professor)

Participants (6)

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CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

UNIVERSITY PABLO DE OLAVIDE

Spain

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

TAMPEREEN TEKNILLINEN YLIOPISTO

Finland

MAX PLANCK INSTITUTE FOR BRAIN RESEARCH

Germany

UNIVERSITE JOSEPH FOURIER GRENOBLE 1

France

Project information

Grant agreement ID: 43309

  • Start date

    1 January 2007

  • End date

    31 December 2009

Funded under:

FP6-POLICIES

  • Overall budget:

    € 2 410 993

  • EU contribution

    € 1 599 989

Coordinated by:

UNIVERSITAT POLITÈCNICA DE CATALUNYA

Spain