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Morphogenesis and gene regulatory networks in plants and animals: a complex systems modelling approach

Morphogenesis and gene regulatory networks in plants and animals: a complex systems modelling approach

Objective

The main objective of the project is to obtain via a modeling and simulation approach a better understanding of the structure and dynamics of metabolic pathways of gene regulatory networks involved in the morphogenesis of animals and plants. We will concentrate on the development of two kind of sponges and on the organogenesis of carpel and anthers of a flowering plant.

We will tackle the complexity involved in these processes by using concepts and tools arising from complex systems science. On the one side morphogenesis of sponges and organogenesis in flowering plants share many common concerns and approaches which justify the feasibility of tackling them within a common complex systems framework. On the other side they consider distinguished features and methods of analysis that will guarantee a minimal genericity in the tools designed for the modeling process.

The following problems will be addressed: provide a general model allowing to describe the underlying complex systems at different hiearchical levels in the same formalism; provide tools to extract concrete models description from experimental data; provide a way to conduct in-silico experiments. These tools will be applied on real data in order to significatively progress on the initial biological problems and will also be used to develop a model-guided data collection process. Moreover, the simulation tools will be modular enough to be customized or extended in the future for modeling complex systems arising from other fields.

Our global goals can be summarized by three measurable and verifiable objectives: to build spatiotemporal atlases of gene expression for flowering plants (for carpel and anther) and one for sponges; to design, implement and finely tune models of development for reproductive organs in flowering plants and for sponges; to develop a customizable modeling and simulation platform adapted to the study of complex systems in the context of development biology.

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Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Address

Rue Michel-Ange 3
Paris

France

Administrative Contact

Eric BOIX (Dr)

Participants (7)

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UNIVERSITEIT VAN AMSTERDAM

Netherlands

CHALMERS TEKNISKA HOEGSKOLA AKTIEBOLAG

Sweden

CORPORACION DE CIENCIAS Y DE LA EDUCACION - INSTITUTO DE SISTEMAS COMPLEJOS DE VALPARAISO

Chile

JOHANNES GUTENBERG-UNIVERSITAT

Germany

OSLO

France

UNIVERSITÄT STUTTGART

Germany

UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ

Germany

Project information

Grant agreement ID: 43322

  • Start date

    1 January 2007

  • End date

    31 December 2009

Funded under:

FP6-POLICIES

  • Overall budget:

    € 2 227 281

  • EU contribution

    € 1 599 990

Coordinated by:

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France