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Improving the safety of blood and organ supply by creating the research infrastructure to monitor emerging pathogens and develop new screening tests

Objective

In Western Europe, blood and organ safety is not guaranteed for several reasons:
- Emerging novel infectious agents and mutating known viruses remain a permanent threat;
- Currently, it takes many years to assess the clinical relevance of new/mutated pathogens and to take appropriate measures;
- Appropriate and cost-effective screening procedures (e.g. not all blood-borne viruses are screened for, viruses mutate and may escape detection) are not fully available;
- 30-40% of recipients are immunodeficient and at considerably higher risk of infection and of pathogenic consequences than those immunocompetent.

However, this higher level of risk has not been addressed adequately and specific safety measures to reduce it remain to be defined. BOTIA aims to improve safety of blood transfusion/ organ transplantation by:
- The creation of an infrastructure consisting of an EU-wide sample repository of paired donor and recipient samples that will enable fast assessment of emerging blood borne agents such that appropriate measures can be taken without delay. This repository will also be a valuable tool for studying new safety aspects of already known viruses in relation to immunodeficiency and for carrying out retrospective studies once new viruses are identified after completing the BOTIA project;
- The identification of novel/mutated blood and organ borne viruses by applying a PCR-based assay, enabling detection of viral DNA or RNA without a priori knowledge about the agent genome;
- The improvement of donor screening in a number of ways:
a) identifying limitations in current screening procedures;
b) developing more cost-effective and safer screening procedures for EU countries (multiplex screening assays),
c) developing inexpensive and simple test procedures for newly discovered viruses for less developed countries.
On the basis of results, BOTIA will produce a range of recommendations to sanitary authorities.

Coordinator

INSTITUT NATIONAL DE LA TRANSFUSION SANGUINE

Address

6 Rue Alexandre-Cabanel
Paris

France

Participants (8)

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THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

OSPEDALE A.MANZONI, LECCO

Italy

SCIENTIFIC INSTITUTE OF PUBLIC HEALTH

Belgium

SERVEIS SANITARIS DE REFERÈNCIA-CENTRE DE TRANSFUSIO I BANC DE TEIXITS

Spain

ACADEMIC MEDICAL CENTER, UNIVERSITY OF AMSTERDAM

Netherlands

DRK BLUTSPENDEDIENST BADEN-WÜRTTEMBERG - HESSEN GGMBH, INSTITUT FÜR TRANSFUSIONMEDIZIN

Germany

RESEAUMATIQUE S.A.

France

INSTYTUT HEMATOLOGII I TRANSFUZJOLOGII

Poland

Project information

Grant agreement ID: 6487

  • Start date

    1 August 2006

  • End date

    31 July 2010

Funded under:

FP6-POLICIES

  • Overall budget:

    € 2 328 295

  • EU contribution

    € 2 091 095

Coordinated by:

INSTITUT NATIONAL DE LA TRANSFUSION SANGUINE

France