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Quantification of cancer and non-cancer risks associated with multiple chronic radiation exposures: epidemiological studies, organ dose calculation and risk assessment

Objective

Radiation protection guidelines are mainly based on studies of populations exposed to external radiation. This project regroups major European studies able to evaluate long term health effects after internal exposure to radionuclides (radon, uranium, plutonium). Large cohort and case-trol studies aim to quantify the effect of multiple exposures, taking into account specific organ dose calculation, the tribution of each radionuclides and external exposure. All selected studies are characterized by precise registration of individual annual exposure: -German, French and Czech Uranium miner cohorts, implemented during a FP5 project will inform on quantification of risk for various cancers (lung, kidney, leukaemia) and non-cancer in relation to calculated organ dose by producing recent data, but also including dust and gamma exposure. -European case-trol studies on lung cancer and domestic radon gives the opportunity to compare these risk estimates with those from worker studies and to calculate attributable risk for low protracted exposures to alpha particles and interactions with tobacco. -Specific studies of nuclear workers in which doses due to internal taminations will be restructed individually, especially in the UK, France and Belgium. The main interest will be on lung cancer and leukaemia risk, through nested case-trol studies. Implementation of a joint French-English cohort will provide the bases for studies of long term health effects of internal and external exposures. Uncertainties linked to exposure estimates will be introduced into dose-risk models. Researchers in epidemiology, statistics, modelling and dosimetry will stitute a European panel supporting the data analysis and the interpretation of results. This project will provide integrated results regarding effects of chronic internal radiation exposures, complementarily to other ongoing work, mainly on Mayak.

Call for proposal

EURATOMCALL2004-FIXEDDEADLINE
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Funding Scheme

STREP - Specific Targeted Research Project
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Coordinator

INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIRE
Address
77-83 Avenue Du General De Gaulle
Clamart
France

Participants (18)

BUNDESAMT FUER STRAHLENSCHUTZ
Germany
Address
Willy-brandt-strasse 5
10149 Salzgitter
STATNI USTAV RADIACNI OCHRANY
Czechia
Address
Bartoskova 28
Praha
CANCER RESEARCH UK
United Kingdom
Address
Lincoln's Inn Field 61
London
INTERNATIONAL AGENCY FOR RESEARCH ON CANCER
France
Address
Cours Albert-thomas 150
Lyon
WESTLAKES SCIENTIFIC CONSULTING LIMITED
United Kingdom
Address
Westlakes Science And Technology Park
Moor Row / Cumbria
AWE PLC
United Kingdom
Address
Aldermaston
Reading / Berkshire
HEALTH PROTECTION AGENCY
United Kingdom
Address
330 High Holborn - Holborn Gate - 7Th Floor
London
UNIVERSITAET SALZBURG
Austria
Address
Kapitelgasse 4-6
Salzburg
HELMHOLTZ ZENTRUM MUNCHEN DEUTSCHESFORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT GMBH
Germany
Address
Ingolstaedter Landstrasse 1
Neuherberg
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU (RIVM)
Netherlands
Address
Antonie Van Leeuwenhoeklaan 9
Postbus 1 Bilthoven
ISTITUTO SUPERIORE DI SANITA
Italy
Address
Viale Regina Elena 299
Roma
BUNDESANSTALT FUER ARBEITSSCHUTZ UND ARBEITSMEDIZIN
Germany
Address
Noeldnerstrasse 40-42
Berlin
CAATS SARL
France
Address
25 Avenue De L'europe
Sevres
UNITED KINGDOM ATOMIC ENERGY AUTHORITY
United Kingdom
Address
Harwell International Business Centre
Didcot
STUDIECENTRUM VOOR KERNENERGIE - CENTRE D'ETUDE DE L'ENERGIE NUCLEAIRE
Belgium
Address
Herrmann Debrouxlaan 40-42
Bruxelles
UNIVERSITY OF OTTAWA
Canada
Address
550 Cumberland Street
Ottawa
NUVIA LIMITED
United Kingdom
Address
Kelburn Court - Daten Park
Risley / Warrington
FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL
Spain
Address
C/ Doctor Aiguader, 88
Barcelona