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Genetic component of the low dose risk of thyroid cancer

Objective

Cancer of the non-medullary (follicular epithelium) component of the thyroid is induced by external irradiation and by radionuclides deposited within the thyroid tissues. Estimates of the radiological risk of developing thyroid cancer are derived from epidemiological studies performed in populations receiving high doses. Extrapolation of this risk to exposures at much lower doses is compromised by the lack of an accurate model of the dose response curve for thyroid cancer at low doses. Moreover, such population-based estimates fail to take into account the contribution of individual genetic variability to the risk estimate. Individuals with an increased genetic predisposition to develop thyroid cancer are not identified, and it is precisely these individuals who will be at greatest risk at low doses. The GENRISK-T consortium is composed of thyroid cancer experts with experience in the fields of radiation biology, animal models of radiation-induced cancer, tumour banking, cancer biology, molecular genetics, histopathology, cytogenetics and risk modelling. We will use this interdisciplinary knowledge to define the genetic component influencing the risk of radiation-induced thyroid cancer. This will be achieved through a combination of studies using animal models and in human radiation-induced thyroid tumours. This new understanding of genetic risk modifiers will be used to develop an animal model of thyroid cancer that is responsive to low dose radiation in the cGy range, thereby providing an experimental solution to resolving the uncertainties of the low dose response curve.

Call for proposal

EURATOM-2005-6-FIXEDDEADLINE
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Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Address
Ingolstaedter Landstrasse 1
Neuherberg
Germany

Participants (9)

COMMISSARIAT A L'ENERGIE ATOMIQUE (CEA)
France
Address
Batiment Le Ponant D - 25 Rue Leblanc
Paris
UNIVERSITY OF WALES SWANSEA
United Kingdom
Address
Singleton Park
Swansea
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
Address
Exhibition Road
London
MARIA SKLODOWSKA-CURIE MEMORIAL CANCER CENTER
Poland
Address
Roentgena 5
Warzawa W.k.
UNIVERSITE LIBRE DE BRUXELLES
Belgium
Address
Avenue Franklin Roosevelt 50
Brussels
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II.
Italy
Address
Corso Umberto I, 40
Napoli
STUDIECENTRUM VOOR KERNENERGIE - CENTRE D'ETUDE DE L'ENERGIE NUCLEAIRE
Belgium
Address
Avenue Hermann-debroux 40
Brussels
CENTRO DE INVESTIGACIONES ENERGETICAS, MEDIOAMBIENTALES Y TECNOLOGICAS-CIEMAT
Spain
Address
Av. Comlutense 22
Madrid
ASCENION GMBH
Germany
Address
Herzogstrasse 68
Munich